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GLO1 regulates hepatocellular carcinoma proliferation and migration through the cell cycle pathway

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收录情况： ◇ SCIE

作者：
Yao Zhang[1,2,3] * ; Xiaolong Tang[1,2,3] * ; Lin Liu[1,2,3] * ; Dan Cai[1,2,3] ; Shuang Gou[1,2,3] ; Siyu Hao[1,2,3] ; Yan Li[5] ; Jing Shen[1,2,3] ; Yu Chen[1,2,3] ; Yueshui Zhao[1,2,3] ; Xu Wu[1,2,3] ; Mingxing Li[1,2,3] ; Meijuan Chen[1] ; Xiaobing Li[1] ; Yuhong Sun[1] ; Li Gu[1] ; Wanping Li[1] ; Fang Wang[1] ; Zhuo Zhang[6] ; Xiaodong Wang[7] ; Shuai Deng[1,2,3] ; Zhangang Xiao[1,2,3,4] ; Lei Yao[8,9] ; Fukuan Du[1,2,3] ;
机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China [2]Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, Sichuan 646000, China [3]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan 646000, China [4]Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China [5]Public Center of Experimental Technology, Southwest Medical University, Luzhou, Sichuan 646000, China [6]Key Laboratory of Luzhou City for Aging Medicine, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China [7]Department of Hepatobiliary Disease, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China [8]The Key Laboratory for Human Disease Gene Study of Sichuan Province and Department of Laboratory Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China [9]Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences, Chengdu 610072, China
出处：
DOI： 10.1186/s12885-024-12927-x

关键词： GLO1 Hepatocellular carcinoma Cell cycle Biomarker Therapeutic target

摘要：
Hepatocellular carcinoma (HCC) is a malignant tumor characterized by a high mortality rate. The occurrence and progression of HCC are linked to oxidative stress. Glyoxalase-1 (GLO1) plays an important role in regulating oxidative stress, yet the underlying mechanism remains unclear. GLO1 may serve as a prognostic biomarker and therapeutic target for HCC.Based on TCGA database hepatocellular carcinoma samples, we conducted a bioinformatics analysis to explore the correlation between GLO1 expression and HCC cell proliferation and viability. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that differentially expressed genes (DEGs) were mainly enriched in the cell cycle pathway. We analyzed the relationships between GLO1 and 24 genes enriched in the cell cycle pathway using a protein-protein interaction (PPI) network. Finally, experimental validation was performed to assess GLO1's impact on the distribution of cells at different cell cycle stages and on the proliferation and migration of HCC cells.Our study demonstrated that GLO1 was overexpressed in HCC tissues and was associated with a poor prognosis. Data analysis indicated that overexpression of GLO1 activated the cell cycle pathway and positively correlated with expression of the majority of key cell cycle genes. Experimental validation showed that GLO1 expression affects the number of HCC cells in G2 and S phases and regulates HCC cell proliferation and migration.GLO1 represents a promising therapeutic target for HCC, providing valuable insights into its role in the viability and proliferation of HCC cells.© 2024. The Author(s).

基金：
This study was supported by grants from the Sichuan Science and Technology Program, China (No. 2022NSFSC0783, No. 2022YFS0619), the Joint Founds of Southwest Medical University and Luzhou Government (No.2020LZXNYDJ08), Grants of Southwest Medical University (2021ZKMS038), Funds of talent introduction and scientific research of Southwest Medical University (No.05- 00040140), The Project of Science and Technology Department of Sichuan Provincial of China to L.Y. (2019JDJQ0035).
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外文
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出版当年[2024]版：
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最新[2023]版：
大类 | 2 区 医学
小类 | 3 区 肿瘤学
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出版当年[2024]版：
无
最新[2023]版：
Q2 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China [2]Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, Sichuan 646000, China [3]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan 646000, China
共同第一作者：
通讯作者：
通讯机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China [2]Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, Sichuan 646000, China [3]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan 646000, China [4]Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China [8]The Key Laboratory for Human Disease Gene Study of Sichuan Province and Department of Laboratory Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China [9]Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences, Chengdu 610072, China
推荐引用方式(GB/T 7714)：
Yao Zhang,Xiaolong Tang,Lin Liu,et al.GLO1 regulates hepatocellular carcinoma proliferation and migration through the cell cycle pathway[J].BMC Cancer.2024,24(1):1297.doi:10.1186/s12885-024-12927-x.
APA：
Yao Zhang,Xiaolong Tang,Lin Liu,Dan Cai,Shuang Gou...&Fukuan Du.(2024).GLO1 regulates hepatocellular carcinoma proliferation and migration through the cell cycle pathway.BMC Cancer,24,(1)
MLA：
Yao Zhang,et al."GLO1 regulates hepatocellular carcinoma proliferation and migration through the cell cycle pathway".BMC Cancer 24..1(2024):1297

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