机构：[1]Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.四川大学华西医院[2]Department of Chemical and Biomolecular Engineering, Samueli School of Engineering, University of California at Los Angeles, Los Angeles, California 90095, United States.[3]National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610041, China.[4]Institute of Respiratory Health, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.四川大学华西医院[5]Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.四川大学华西医院[6]Department of Radiology, Sanya People's Hospital, Sanya, Hainan 572022, China.[7]Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan 610041, China.
Traditional macromolecules or nanoscale Mn2+ chelate-based magnetic resonance imaging (MRI) contrast agents (CAs) suffer from complicated and laborious synthesis processes, relatively low kinetic stability and T1 relaxivity, limiting their clinical applications. Herein, we fabricated a series of kinetically inert Mn2+ chelate-backboned polymers, P(MnL-PEG), through a facile and one-pot polymerization process. Particularly, P(MnL-PEG)-3 demonstrates a significantly higher T1 relaxivity of 23.9 Mn mM-1 s-1 at 1.5 T than that of previously reported small molecules and macromolecules or nanoscale Mn2+ chelate-based CAs. Due to its high T1 relaxivity, extended blood circulation, hepatocyte-specific uptake, and kidneys metabolism, P(MnL-PEG)-3 presents significantly enhanced contrast in blood vessel, liver, and kidneys imaging compared to clinical Gd3+-based CAs (Gd-EOB-DTPA and Gd-DOTA) at a dosage of 0.05 mmol Mn/Gd kg-1 BW, and can accurately diagnose orthotopic H22 liver tumors in vivo in animal models. We anticipate that this work will promote the development of clinically relevant MRI CAs.
基金：
This work was supported by the National Natural Science
Foundation of China (No. 82402351, China), the China
Postdoctoral Science Foundation Funded Project (No.
2023M732440, China), the Natural Science Foundation of
Sichuan Province (No. 2023NSFSC1727, China), the
Postdoctor Research Fund of West China Hospital, Sichuan
University (No. 2024HXBH048, China), the 1.3.5 Project for
Disciplines of Excellence, West China Hospital, Sichuan
University (No. ZYGD22004, China), the Scientific and
Technological Achievements Transformation Fund of West
China Hospital, Sichuan University (No. CGZH21002,
China), and the Innovative Research Project of Sichuan
University (No. 2022SCUH0013, China).
第一作者机构：[1]Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
通讯作者：
通讯机构：[1]Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.[7]Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan 610041, China.
推荐引用方式(GB/T 7714)：
Fu Shengxiang,Younis Muhammad Rizwan,Cai Zhongyuan,et al.One-Pot Fabrication of Kinetically Inert Ultrasmall Manganese(II) Chelate-Backboned Polymer Contrast Agents for High-Performance Magnetic Resonance Imaging[J].Nano Letters.2024,doi:10.1021/acs.nanolett.4c03804.
APA：
Fu Shengxiang,Younis Muhammad Rizwan,Cai Zhongyuan,Liu Li,Gu Haojie...&Wu Min.(2024).One-Pot Fabrication of Kinetically Inert Ultrasmall Manganese(II) Chelate-Backboned Polymer Contrast Agents for High-Performance Magnetic Resonance Imaging.Nano Letters,,
MLA：
Fu Shengxiang,et al."One-Pot Fabrication of Kinetically Inert Ultrasmall Manganese(II) Chelate-Backboned Polymer Contrast Agents for High-Performance Magnetic Resonance Imaging".Nano Letters .(2024)
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