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Synthetic nanomaterials for spleen-specific mRNA delivery

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资源类型：
Pubmed体系：
作者：
Nie Shihong[1] ; Yang Beiqi[1,2] ; Ma Ruiying[1,2] ; Zha Lili[2] ; Qin Yuyang[2] ; Ou Liyuan[2] ; Chen Xiaoyuan[3,4,5,6,7] ; Li Ling[2] ;
机构： [1]Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China. [2]West China School of Public Health and West China Fourth Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China. [3]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, Singapore [4]Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore [5]Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore [6]Theranostics Center of Excellence (TCE), Yong Loo Lin School of Medicine, National University of Singapore, 11 Biopolis Way, Helios, 138667, Singapore [7]Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (ASTAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore.
出处：
DOI： 10.1016/j.biomaterials.2024.122859
ISSN：

关键词： mRNA delivery Spleen LNPs Lipoplexes Polyplexes

摘要：
In recent years, mRNA vaccine has achieved increasing interest owing to its high potency, safety, ease of production, and low-cost manufacturing. Currently approved mRNA vaccines are administered intramuscularly to transfect local antigen-presenting cells (APCs) to initiate low to moderate immune responses. Spleen, the largest secondary lymphoid organ in the body which contains a large number of APCs close to B and T lymphocytes, could be the ideal site for effective initiation of an enhanced immune response. Here, we provide an overview of the recent advances in the development of synthetic materials for spleen-specific mRNA delivery, and lipid nanoparticle-based approaches will be highlighted. We further discuss the main challenges for spleen-specific mRNA delivery to provide a reference for the development of next-generation synthetic nanomaterials with optimal properties.Copyright © 2024 Elsevier Ltd. All rights reserved.

基金：
This work was supported by National Natural Science Foundation of China (No. NSFC 82202311), National University of Singapore (NUHSRO/2020/133/Startup/08, NUHSRO/2023/008/NUSMed/TCE/ LOA, NUHSRO/2021/034/TRP/09/Nanomedicine, NUHSRO/2021/ 044/Kickstart/09/LOA, 23-0173-A0001), National Medical Research Council (MOH-001388-00, CG21APR1005, MOH-001500-00, MOH- 001609-00), Singapore Ministry of Education (MOE-000387-00), and National Research Foundation (NRF-000352-00).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
第一作者：
第一作者机构： [1]Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
通讯作者：
通讯机构： [3]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, Singapore [4]Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore [5]Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore [6]Theranostics Center of Excellence (TCE), Yong Loo Lin School of Medicine, National University of Singapore, 11 Biopolis Way, Helios, 138667, Singapore [7]Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (ASTAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore.
推荐引用方式(GB/T 7714)：
Nie Shihong,Yang Beiqi,Ma Ruiying,et al.Synthetic nanomaterials for spleen-specific mRNA delivery[J].Biomaterials.2024,314:122859.doi:10.1016/j.biomaterials.2024.122859.
APA：
Nie Shihong,Yang Beiqi,Ma Ruiying,Zha Lili,Qin Yuyang...&Li Ling.(2024).Synthetic nanomaterials for spleen-specific mRNA delivery.Biomaterials,314,
MLA：
Nie Shihong,et al."Synthetic nanomaterials for spleen-specific mRNA delivery".Biomaterials 314.(2024):122859

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