Association of the Number of Concurrent Metabolic Syndrome Risk Factors with Textbook Outcomes Following Liver Resection for Patients with Hepatocellular Carcinoma: A Multicenter Study
机构:[1]Sichuan Univ, West China Hosp, Dept Liver Surg, Chengdu, Sichuan, Peoples R China四川大学华西医院[2]Chinese Univ Hong Kong, Med Data Analyt Ctr, Dept Med & Therapeut, Hong Kong, Peoples R China[3]Chinese Univ Hong Kong, Inst Digest Dis, State Key Lab Digest Dis, Hong Kong, Peoples R China[4]Sichuan Prov Peoples Hosp, Dept HPB Surg, Chengdu, Peoples R China四川省人民医院[5]First Peoples Hosp Neijiang, Dept HPB Surg, Neijiang, Peoples R China[6]Second Peoples Hosp Yibin, Dept HPB Surg, Yibin, Peoples R China[7]Chengdu Univ, Affiliated Hosp, Dept HPB Surg, Chengdu, Peoples R China
Background. There is little information regarding the impact of the number of concurrent metabolic syndrome (MetS) risk factors on the textbook outcomes (TO) in patients with hepatocellular carcinoma (HCC) following liver resection. Patients and Methods. Data from patients who underwent liver resection between 2015 and 2023 in a multicenter database were retrospectively reviewed (N = 3156). According to the guidelines, MetS risk factors include obesity, hypertension, diabetes, and dyslipidemia. Results. In this study, 2056 (65.1%) patients achieved TO. The incidence of TO was 63.1% in patients with >= 1 MetS risk factor, which was lower than that in patients without any MetS risk factors (67.5%, P = 0.011). As the number of MetS risk factors increased, the probability of not achieving TO gradually increased. The non-TO rates in patients with no, 1, 2, and >= 3 MetS risk factors were 32.5%, 35.9%, 37.6% and 40.2%, respectively (P-trend = 0.005). Multivariate logistic regression confirmed that the number of MetS risk factors (0 as a reference; 1, OR 1.220, 95% CI 1.029-1.447, P = 0.022; 2, OR 1.397, 95% CI 1.113-1.755, P = 0.004; >= 3, OR 1.647, 95% CI 1.197-2.264, P = 0.002) independently contributed to non-TO in patients with HCC after liver resection. Both the 5-year recurrence-free survival (TO: 50.7% versus non-TO: 43.9%, P < 0.001) and overall survival rates (TO: 71.0% versus non-TO: 58.7%, P < 0.001) of TO patients were significantly better than those of non-TO patients. Conclusions. Concurrent MetS risk factors can adversely impact TO achievement in patients with HCC after liver resection. The more risk factors patients have, the less likely they are to achieve TO.
基金:
Natural Science Foundation of Sichuan Province [2024NSFSC0637]; Natural Science Foundation of Sichuan Province
第一作者机构:[1]Sichuan Univ, West China Hosp, Dept Liver Surg, Chengdu, Sichuan, Peoples R China
通讯作者:
推荐引用方式(GB/T 7714):
Qiu Zhan-Cheng,Dai Jun-Long,Zhang Yu,et al.Association of the Number of Concurrent Metabolic Syndrome Risk Factors with Textbook Outcomes Following Liver Resection for Patients with Hepatocellular Carcinoma: A Multicenter Study[J].ANNALS OF SURGICAL ONCOLOGY.2025,32(1):399-407.doi:10.1245/s10434-024-16343-0.
APA:
Qiu, Zhan-Cheng,Dai, Jun-Long,Zhang, Yu,Xie, Fei,Yu, Yu...&Li, Chuan.(2025).Association of the Number of Concurrent Metabolic Syndrome Risk Factors with Textbook Outcomes Following Liver Resection for Patients with Hepatocellular Carcinoma: A Multicenter Study.ANNALS OF SURGICAL ONCOLOGY,32,(1)
MLA:
Qiu, Zhan-Cheng,et al."Association of the Number of Concurrent Metabolic Syndrome Risk Factors with Textbook Outcomes Following Liver Resection for Patients with Hepatocellular Carcinoma: A Multicenter Study".ANNALS OF SURGICAL ONCOLOGY 32..1(2025):399-407