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Association of Preoperative Body Mass Index with Surgical Textbook Outcomes Following Hepatectomy for Hepatocellular Carcinoma: A Multicenter Study of 1206 Patients

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机构: [1]Department of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University),Chongqing, China [2]Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second MilitaryMedical University (Navy Medical University), Shanghai, China [3]Division of Hepatobiliary and Pancreatic Surgery,Department of General Surgery, Cancer Center, Zhejiang Provincial People’s Hospital, People’s Hospital of HangzhouMedical College, Zhejiang, China [4]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui MedicalUniversity, Anhui, China [5]Department of Hepatobiliary Surgery, Affiliated Hospital of Nantong University, Jiangsu,China [6]The First Department of General Surgery, The Fourth Hospital of Harbin, Heilongjiang, China [7]Department ofHepatobiliary Surgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang, China [8]Department ofGeneral Surgery, Ziyang First People’s Hospital, Sichuan, China [9]Department of Hepatobiliary Surgery, Pu’er People’sHospital, Yunnan, China [10]Department of General Surgery, Liuyang People’s Hospital, Hunan, China [11]Department ofSurgery, Wexner Medical Center, Ohio State University, Columbus, OH [12]Faculty of Medicine, The Chinese University ofHong Kong, Shatin, New Territories, Hong Kong SAR, China [13]Eastern Hepatobiliary Clinical Research Institute(EHCRI), Third Affiliated Hospital of Navy Medical University, Shanghai, China
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Background Assessment of quality in the perioperative period is critical to ensure good patient care. Textbook outcomes (TO) have been proposed to combine several parameters into a single defined quality metric. The association of preoperative body mass index (BMI) with incidences of achieving or not achieving TO (non-TO) among patients undergoing hepatectomy for hepatocellular carcinoma (HCC) was characterized. Methods Patients who underwent curative-intent hepatectomy for HCC between 2015 and 2018 were identified from a multicenter database. These patients were divided into three groups based on preoperative BMI: low-BMI (<= 18.4 kg/m(2)), normal-BMI (18.5-24.9 kg/m(2)), and high-BMI (>= 25.0 kg/m(2)). The incidences of non-TO among these three groups were compared. Multivariate analyses were performed to identify whether there was any independent association between preoperative BMI and non-TO. Results Among 1206 patients, 100 (8.3%), 660 (54.7%), and 446 (37.0%) were in the low-BMI, normal-BMI, and high-BMI groups, respectively. The incidence of non-TO was 65.6% in the whole cohort. The incidence of non-TO was significantly higher among patients in the low- and high-BMI cohorts versus the normal-BMI cohort (75.0% and 74.7% versus 58.0%, both P < 0.01). After adjustment of other confounding factors on multivariate analysis, low-BMI and high-BMI were independently associated with higher incidences of non-TO compared with normal-BMI (OR: 1.98 and 2.27, both P < 0.05). Conclusions Two out of three patients did not achieve TO after hepatectomy for HCC. Both preoperative low-BMI and high-BMI were independently associated with lower odds to achieve optimal TO following HCC resection.

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出版当年[2022]版:
大类 | 2 区 医学
小类 | 2 区 肿瘤学 2 区 外科
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 外科 3 区 肿瘤学
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出版当年[2022]版:
Q1 SURGERY Q2 ONCOLOGY
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Q1 SURGERY Q2 ONCOLOGY

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第一作者机构: [1]Department of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University),Chongqing, China
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通讯机构: [2]Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second MilitaryMedical University (Navy Medical University), Shanghai, China [3]Division of Hepatobiliary and Pancreatic Surgery,Department of General Surgery, Cancer Center, Zhejiang Provincial People’s Hospital, People’s Hospital of HangzhouMedical College, Zhejiang, China [13]Eastern Hepatobiliary Clinical Research Institute(EHCRI), Third Affiliated Hospital of Navy Medical University, Shanghai, China
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