机构：[1]School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.[2]Department of Medical Imaging, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.[3]Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.[4]Department of General Surgery (Thyroid Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.[5]Department of Cardiology, Institute of Cardiovascular Research, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
The tetraspanin family of membrane proteins is essential for controlling different biological processes such as cell migration, penetration, adhesion, growth, apoptosis, angiogenesis and metastasis. The present review summarized the current knowledge regarding the expression and roles of tetraspanins in different types of cancer of the digestive system, including gastric, liver, colorectal, pancreatic, esophageal and oral cancer. Depending on the type and context of cancer, tetraspanins can act as either tumor promoters or suppressors. In the present review, the importance of tetraspanins in serving as biomarkers and targets for different types of digestive system‑related cancer was emphasized. Additionally, the molecular mechanisms underlying the involvement of tetraspanins in cancer progression and metastasis were explored. Furthermore, the current challenges are addressed and future research directions for advancing investigations related to tetraspanins in the context of digestive system malignancies are proposed.
基金：
The present study was supported by the National Natural
Science Foundation of China (grant no. 82030007); National
Natural Science Foundation of China (grant no. U23A20398);
The Central Government Guides Local Science and
Technology Development Project (grant no. 2022ZYD0057);
Natural Science Foundation of Sichuan Province (grant
no. 2024NSFSC0580); the Applied Basic Research Program
of Sichuan Province (grant nos. 2023NSFSC1840 and
2021YJ0200); the Sichuan Science and Technology Program
(grant nos. 2022YFS0630, 2022YFS0627, 2022YFS0578 and
2022YFS0614); the Science and Technology Project of Luzhou
Government (grant nos. 2022YFS0630‑B1, 2022YFS0627‑A1
and 2022YFS0614-A1); and the Southwest Medical University
(grant no. 2021ZKMS005).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类|3 区医学
小类|4 区医学：研究与实验4 区肿瘤学
第一作者：
第一作者机构：[1]School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
共同第一作者：
通讯作者：
通讯机构：[1]School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.[5]Department of Cardiology, Institute of Cardiovascular Research, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
推荐引用方式(GB/T 7714)：
Chen Kexin,Li Qiuhong,Li Yangyi,et al.Tetraspanins in digestive-system cancers: Expression, function and therapeutic potential (Review)[J].Molecular Medicine Reports.2024,30(5):doi:10.3892/mmr.2024.13324.
APA：
Chen Kexin,Li Qiuhong,Li Yangyi,Jiang Donghui,Chen Ligang...&Zhang Chunxiang.(2024).Tetraspanins in digestive-system cancers: Expression, function and therapeutic potential (Review).Molecular Medicine Reports,30,(5)
MLA：
Chen Kexin,et al."Tetraspanins in digestive-system cancers: Expression, function and therapeutic potential (Review)".Molecular Medicine Reports 30..5(2024)
