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Molecular subtypes of colorectal cancer in the era of precision oncotherapy: Current inspirations and future challenges

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收录情况： ◇ SCIE

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机构： [1]Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. [2]Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. [3]Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. [4]Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [5]Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. [6]Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. [7]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. [8]Interventional Treatment and Clinical Research Center of Henan Province, Zhengzhou, Henan, China. [9]Interventional Institute of Zhengzhou University, Zhengzhou, Henan, China. [10]Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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关键词： CMS classification colorectal cancer heterogeneity molecular subtype precision oncotherapy

摘要：

Colorectal cancer (CRC) is among the most hackneyed malignancies. Even patients with identical clinical symptoms and the same TNM stage still exhibit radically different clinical outcomes after receiving equivalent treatment regimens, indicating extensive heterogeneity of CRC. Myriad molecular subtypes of CRC have been exploited for decades, including the most compelling consensus molecular subtype (CMS) classification that has been broadly applied for patient stratification and biomarker-drug combination formulation. Encountering barriers to clinical translation, however, CMS classification fails to fully reflect inter- or intra-tumor heterogeneity of CRC. As a consequence, addressing heterogeneity and precisely managing CRC patients with unique characteristics remain arduous tasks for clinicians.In this review, we systematically summarize molecular subtypes of CRC and further elaborate on their clinical applications, limitations, and future orientations.In recent years, exploration of subtypes through cell lines, animal models, patient-derived xenografts (PDXs), organoids, and clinical trials contributes to refining biological insights and unraveling subtype-specific therapies in CRC. Therapeutic interventions including nanotechnology, clustered regulatory interspaced short palindromic repeat/CRISPR-associated nuclease 9 (CRISPR/Cas9), gut microbiome, and liquid biopsy are powerful tools with the possibility to shift the immunologic landscape and outlook for CRC precise medicine.© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

JCR分区：

出版当年[2023]版：

Q2 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 2.9 最新[2023版] 3.9 最新五年平均 2.9 出版当年[2023版] 0 出版当年五年平均 2.9 出版前一年[2023版]

第一作者：

第一作者机构： [1]Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. [2]Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

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通讯作者：

通讯机构： [1]Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. [8]Interventional Treatment and Clinical Research Center of Henan Province, Zhengzhou, Henan, China. [9]Interventional Institute of Zhengzhou University, Zhengzhou, Henan, China. [10]Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [*1]Department of InterventionalRadiology, The First Affiliated Hospitalof Zhengzhou University, Zhengzhou,Henan, China

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Molecular subtypes of colorectal cancer in the era of precision oncotherapy: Current inspirations and future challenges

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