Downregulation of CLDN6 inhibits cell proliferation, migration, and invasion via regulating EGFR/AKT/mTOR signalling pathway in hepatocellular carcinoma
机构：[1]Chengdu Lilai Biotechnology Co., Ltd, Chengdu, China[2]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, SiChuan University, Chengdu, China[3]Institute of Laboratory Animals of Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu, China四川省人民医院[4]Health Management Center & Physical Examination Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China四川省人民医院
Accumulating evidence showed that the claudin-6 (CLDN6) expression was abnormal in many cancers, while its expression and biological functions in hepatocellular carcinoma (HCC) is still unclear. The present study demonstrated that CLDN6 was upregulated in HCC tissues compared with tumour-adjacent tissues. CLDN6 silencing was significantly inhibited proliferation, migration, and invasion of HepG2 cells. Meanwhile, downregulation of CLDN6 remarkably inhibited the activation of EGFR/AKT/mTOR signalling pathway. Interestingly, the effect of CLDN6 overexpression on HepG2 cell proliferation and invasion could be inhibited by EGFR/AKT/mTOR signalling pathway inhibitor (AG1478). Significance of the study These findings suggested that CLDN6 may act as an oncogene in HCC and improve HepG2 cell proliferation, migration, and invasion may via EGFR/AKT/mTOR signalling pathway.
基金：
Sichuan Health and Family Planning Commission Research Project [17PJ485]
第一作者机构：[1]Chengdu Lilai Biotechnology Co., Ltd, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[3]Institute of Laboratory Animals of Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu, China[4]Health Management Center & Physical Examination Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China[*1]Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, No. 32, West Second Section of the First Ring Road, Qingyang District, Chengdu 610000, China[*2]Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, No. 32,West Second Section of the First Ring Road, Qingyang District, Chengdu, China
推荐引用方式(GB/T 7714)：
Lingyuan Huang,Chanjuan Zhao,Kai Sun,et al.Downregulation of CLDN6 inhibits cell proliferation, migration, and invasion via regulating EGFR/AKT/mTOR signalling pathway in hepatocellular carcinoma[J].CELL BIOCHEMISTRY AND FUNCTION.2020,38(5):541-548.doi:10.1002/cbf.3489.
APA：
Lingyuan Huang,Chanjuan Zhao,Kai Sun,Dandan Yang,Linxia Yan...&Zhendong Zhong.(2020).Downregulation of CLDN6 inhibits cell proliferation, migration, and invasion via regulating EGFR/AKT/mTOR signalling pathway in hepatocellular carcinoma.CELL BIOCHEMISTRY AND FUNCTION,38,(5)
MLA：
Lingyuan Huang,et al."Downregulation of CLDN6 inhibits cell proliferation, migration, and invasion via regulating EGFR/AKT/mTOR signalling pathway in hepatocellular carcinoma".CELL BIOCHEMISTRY AND FUNCTION 38..5(2020):541-548
