Objectives The objective of this study is to summarize the clinical characteristics, treatment, and prognosis of parotid tumors in children and adolescents. Methods Fifty-three children and adolescents diagnosed with parotid gland tumors were included. Survival was evaluated using the Kaplan-Meier method. Log-rank test and multivariate analysis were used to analyze the association between clinical factors and recurrence. Results Of the 53 patients, 30 cases were benign and 23 cases were malignant. All patients underwent surgery. Patients with malignant tumors with high-risk factors received radiotherapy or chemotherapy. The median follow-up time was 61 months. Of these, 1 patient with benign tumor and 5 patients with malignant tumors recurred. Of the patients with malignant tumors, 2 developed distant metastases and 2 died. The 5-year overall survival (OS) and 5-year locoregional recurrence-free survival (LRFS) rates for benign tumors were 100.0% and 92.9%, respectively, whereas the 5-year OS and 5-year LRFS rates for malignant tumors were 94.4% and 72.5%, respectively. The log-rank univariate test showed that tumor size >3.5 cm (p = .056), distant metastasis (p = .056), and stage III and IV (p = .032) were associated with recurrence. However, multivariate analysis did not show the above factors to be independent prognostic factors for LRFS. Conclusion Surgery for benign tumors depends on the location and size. Surgery for malignant parotid tumors depends mainly on the stage, grade, pathological type, and recurrence. Prophylactic lymph node dissection is required for high-grade tumors. Radiotherapy or chemotherapy for children needs more research. Both benign and malignant tumors have high survival rates after active treatment.
基金:
Science and Technology Department of
Sichuan Province, Grant/Award Number:
2019YFS0337
第一作者机构:[1]Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Clin Res Ctr Canc,Sichuan Canc Ctr, Affiliated Canc Hosp,Dept Head & Neck Surg, Chengdu 610041, Peoples R China[2]Univ Elect Sci & Technol China, Sch Med, Chengdu, Peoples R China
通讯作者:
通讯机构:[1]Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Clin Res Ctr Canc,Sichuan Canc Ctr, Affiliated Canc Hosp,Dept Head & Neck Surg, Chengdu 610041, Peoples R China[2]Univ Elect Sci & Technol China, Sch Med, Chengdu, Peoples R China[*1]Department of Head and Neck Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China.
推荐引用方式(GB/T 7714):
Liu Lei,Xiang Yuqing,Shui Chunyan,et al.Long-term follow-up and prognostic analysis of parotid tumors in children and adolescents[J].LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY.2024,9(3):doi:10.1002/lio2.1275.
APA:
Liu, Lei,Xiang, Yuqing,Shui, Chunyan,Li, Chao,Xiong, Lujing...&Cai, Yongcong.(2024).Long-term follow-up and prognostic analysis of parotid tumors in children and adolescents.LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY,9,(3)
MLA:
Liu, Lei,et al."Long-term follow-up and prognostic analysis of parotid tumors in children and adolescents".LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY 9..3(2024)