详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Reduced hepatic AdipoR2 by increased glucocorticoid mediates effect of psychosocial stress to elevate serum cholesterol

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University Chengdu, 610041, PR China [2]Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University Chongqing, PR China [3]Department of Thoracic/Head and Neck Medical Oncology, The MD Anderson Cancer Center, University of Texas Houston, TX, USA

出处：

DOI：

ISSN：

关键词： Psychosocial stress Glucocorticoid Liver Adiponectin receptor 2 Serum cholesterol

摘要：

Understanding the effects of psychosocial stress on serum cholesterol may offer valuable insights into the relationship between psychological disorders and endocrine diseases. However, these effects and their underlying mechanisms have not been elucidated yet. Here we show that serum corticosterone, total cholesterol and low-density lipoprotein cholesterol (LDL-C) are elevated in a mouse model of psychosocial stress. Furthermore, alterations occur in AdipoR2-mediated AMPK and PPARα signaling pathways in liver, accompanied by a decrease in LDL-C clearance and an increase in cholesterol synthesis. These changes are further verified in wild-type and AdipoR2 overexpression HepG2 cells incubated with cortisol and AdipoR agonist, and are finally confirmed by treating wild-type and hepatic-specific AdipoR2 overexpression mice with corticosterone. We conclude that increased glucocorticoid mediates the effects of psychosocial stress to elevate serum cholesterol by inhibiting AdipoR2-mediated AMPK and PPARα signaling to decrease LDL-C clearance and increase cholesterol synthesis in liver.Copyright © 2024. Published by Elsevier B.V.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2024]版：

无

最新[2023]版：

大类 | 3 区医学

小类 | 3 区内分泌学与代谢 3 区细胞生物学

第一作者：

第一作者机构： [1]Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University Chengdu, 610041, PR China

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Serum high-density lipoprotein cholesterol serves as a prognostic marker for light-chain cardiac amyloidosis. [2]The prognostic value of preoperative serum HDL cholesterol in patients with resectable acral melanoma [3]The effect of preoperative serum triglycerides and high-density lipoprotein-cholesterol levels on the prognosis of breast cancer [4]Identification of glucocorticoid receptor in Drosophila melanogaster. [5]Prognostic value of nutritional and inflammatory indicators in females with esophageal squamous cell cancer: A propensity score matching study [6]Visualized podocyte-targeting and focused ultrasound responsive glucocorticoid nano-delivery system against immune-associated nephropathy without glucocorticoid side effect. [7]阿仑膦酸钠治疗儿童糖皮质激素所致自发性骨折3例报告及文献复习 [8]Expression of glucocorticoid receptor (GR) and clinical significance in adrenocortical carcinoma [9]Comparison of hydrocortisone and prednisone in the glucocorticoid replacement therapy post-adrenalectomy of Cushing's Syndrome [10]Gene Expression Profiling for Differential Diagnosis of Liver Metastases: A Multicenter, Retrospective Cohort Study