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Reduced hepatic AdipoR2 by increased glucocorticoid mediates effect of psychosocial stress to elevate serum cholesterol

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机构： [1]Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University Chengdu, 610041, PR China [2]Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University Chongqing, PR China [3]Department of Thoracic/Head and Neck Medical Oncology, The MD Anderson Cancer Center, University of Texas Houston, TX, USA

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关键词： Psychosocial stress Glucocorticoid Liver Adiponectin receptor 2 Serum cholesterol

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Understanding the effects of psychosocial stress on serum cholesterol may offer valuable insights into the relationship between psychological disorders and endocrine diseases. However, these effects and their underlying mechanisms have not been elucidated yet. Here we show that serum corticosterone, total cholesterol and low-density lipoprotein cholesterol (LDL-C) are elevated in a mouse model of psychosocial stress. Furthermore, alterations occur in AdipoR2-mediated AMPK and PPARα signaling pathways in liver, accompanied by a decrease in LDL-C clearance and an increase in cholesterol synthesis. These changes are further verified in wild-type and AdipoR2 overexpression HepG2 cells incubated with cortisol and AdipoR agonist, and are finally confirmed by treating wild-type and hepatic-specific AdipoR2 overexpression mice with corticosterone. We conclude that increased glucocorticoid mediates the effects of psychosocial stress to elevate serum cholesterol by inhibiting AdipoR2-mediated AMPK and PPARα signaling to decrease LDL-C clearance and increase cholesterol synthesis in liver.Copyright © 2024. Published by Elsevier B.V.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区内分泌学与代谢 3 区细胞生物学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区内分泌学与代谢 3 区细胞生物学

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第一作者机构： [1]Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University Chengdu, 610041, PR China

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