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Screening for lung cancer using thin-slice low-dose computed tomography in southwestern China: a population-based real-world study

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机构： [1]Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. [2]State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, China. [3]Institute of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, China. [4]Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China. [5]West China Clinical Medical College, Sichuan University, Chengdu, China. [6]Institute of Hospital Management, West China Hospital, Sichuan University, Chengdu, China. [7]National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China. [8]Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China. [9]Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China. [10]Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China. [11]The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, China.

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关键词： early diagnosis low-dose computed tomography lung cancer pulmonary nodule thin slice scan

摘要：

Lung cancer is one of the most common malignant tumors threatening human life and health. At present, low-dose computed tomography (LDCT) screening for the high-risk population to achieve early diagnosis and treatment of lung cancer has become the first choice recommended by many authoritative international medical organizations. To further optimize the lung cancer screening method, we conducted a real-world study of LDCT lung cancer screening in a large sample of a healthy physical examination population, comparing differences in lung nodules and lung cancer detection between thin and thick-slice LDCT scanning.A total of 29 296 subjects who underwent low-dose thick-slice CT scanning (5 mm thickness) from January 2015 to December 2015 and 28 058 subjects who underwent low-dose thin-slice CT scanning (1 mm thickness) from January 2018 to December 2018 in West China Hospital were included. The positive detection rate, detection rate of lung cancer, pathological stage of lung cancer, and mortality rate of lung cancer were analyzed and compared between the two groups.The positive rate of LDCT screening in the thin-slice scanning group was significantly higher than that in the thick-slice scanning group (20.1% vs. 14.4%, p < 0.001). In addition, the lung cancer detection rate in the thin-slice LDCT screening positive group was significantly higher than that in the thick-slice scanning group (78.0% vs. 52.9%, p < 0.001).The screening positive rate of low-dose thin-slice CT scanning is higher and more early-stage lung cancer (IA1 stage) can be detected in the screen-positive group.© 2024 The Author(s). Thoracic Cancer published by John Wiley & Sons Australia, Ltd.

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大类 | 3 区医学

小类 | 4 区肿瘤学 4 区呼吸系统

第一作者：

第一作者机构： [1]Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. [2]State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, China. [3]Institute of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, China.

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通讯作者：

通讯机构： [1]Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. [2]State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, China. [3]Institute of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, China. [4]Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China. [9]Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China. [10]Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China. [11]The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, China. [*1]Department of Respiratory and Critical Care Medicine, Institute of Respiratory Health, Center of Precision Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu 610041, China [*2]Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu 610041, China.

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Screening for lung cancer using thin-slice low-dose computed tomography in southwestern China: a population-based real-world study

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