高级检索
当前位置: 首页 > 详情页

HPV-associated cervicovaginal microbiome and host metabolome characteristics

文献详情

资源类型:
Pubmed体系:
机构: [1]Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China [2]Department of Oncology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China [3]Cell Therapy & Cell Drugs Key Laboratory of Luzhou, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China [4]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan, China [5]Yanyuan County Maternal and Child Health and Family Planning Service Center, Xichang, Sichuan, China [6]Yanyuan County People’s Hospital, Xichang, Sichuan, China
出处:

关键词: Human papillomavirus Cervical screening Cervicovaginal microbiota Metabolomics

摘要:
Cervicovaginal microbiome plays an important role in the persistence of HPV infection and subsequent disease development. However, cervicovaginal microbiota varied cross populations with different habits and regions. Identification of population-specific biomarkers from cervicovaginal microbiota and host metabolome axis may support early detection or surveillance of HPV-induced cervical disease at all sites. Therefore, in the present study, to identify HPV-specific biomarkers, cervicovaginal secretion and serum samples from HPV-infected patients (HPV group, n = 25) and normal controls (normal group, n = 17) in Xichang, China were collected for microbiome (16S rRNA gene sequencing) and metabolome (UHPLC-MS/MS) analysis, respectively.The results showed that key altered metabolites of 9,10-DiHOME, α-linolenic acid, ethylparaben, glycocholic acid, pipecolic acid, and 9,12,13-trihydroxy-10(E),15(Z)-octadecadienoic acid, correlating with Sneathia (Sneathia_amnii), Lactobacillus (Lactobacillus_iners), Atopobium, Mycoplasma, and Gardnerella, may be potential biomarkers of HPV infection.The results of current study would help to reveal the association of changes in cervicovaginal microbiota and serum metabolome with HPV infections.© 2024. The Author(s).

基金:
语种:
PubmedID:
中科院(CAS)分区:
出版当年[2023]版:
大类 | 2 区 生物学
小类 | 3 区 微生物学
最新[2023]版:
大类 | 2 区 生物学
小类 | 3 区 微生物学
第一作者:
第一作者机构: [2]Department of Oncology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China [3]Cell Therapy & Cell Drugs Key Laboratory of Luzhou, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China [4]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan, China
共同第一作者:
通讯作者:
通讯机构: [1]Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China [2]Department of Oncology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China [3]Cell Therapy & Cell Drugs Key Laboratory of Luzhou, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China [4]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan, China
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:46425 今日访问量:0 总访问量:3323 更新日期:2024-11-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持:重庆聚合科技有限公司 地址:成都市人民南路四段55号