机构：[1]Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China.四川大学华西医院[2]Department of Orthopedics, Hunan Loudi Central Hospital, Loudi 417000, China.[3]Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China.[4]Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Immunosuppressive elements within the tumor microenvironment are the primary drivers of tumorigenesis and malignant advancement. The presence, as well as the crosstalk between myeloid-derived suppressor cells (MDSCs), osteosarcoma-associated macrophages (OS-Ms), regulatory T cells (Tregs), and endothelial cells (ECs) with osteosarcoma cells cause the poor prognosis of OS. In addition, the consequent immunosuppressive factors favor the loss of treatment potential. Nanoparticles offer a means to dynamically and locally manipulate immuno-nanoparticles, which present a promising strategy for transforming OS-TME. Additionally, chimeric antigen receptor (CAR) technology is effective in combating OS. This review summarizes the essential mechanisms of immunosuppressive cells in the OS-TME and the current immune-associated strategies. The last part highlights the limitations of existing therapies and offers insights into future research directions.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|3 区医学
小类|2 区药学
最新[2023]版：
大类|3 区医学
小类|2 区药学
第一作者：
第一作者机构：[1]Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China.[2]Department of Orthopedics, Hunan Loudi Central Hospital, Loudi 417000, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Cheng Shigao,Wang Huiyuan,Kang Xuejia,et al.Immunotherapy Innovations in the Fight against Osteosarcoma: Emerging Strategies and Promising Progress[J].Pharmaceutics.2024,16(2):doi:10.3390/pharmaceutics16020251.
APA：
Cheng Shigao,Wang Huiyuan,Kang Xuejia&Zhang Hui.(2024).Immunotherapy Innovations in the Fight against Osteosarcoma: Emerging Strategies and Promising Progress.Pharmaceutics,16,(2)
MLA：
Cheng Shigao,et al."Immunotherapy Innovations in the Fight against Osteosarcoma: Emerging Strategies and Promising Progress".Pharmaceutics 16..2(2024)
