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Molecular complexity of intraductal carcinoma of the prostate

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机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

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关键词： DNA damage and repair Intraductal carcinoma of the prostate MED12 molecular characteristics MYC NCOR2 prostate acinar adenocarcinoma PTEN RB1 SChLAP1 targeted therapy TMPRSS2-ERG fusion TP53

摘要：

Intraductal carcinoma of the prostate (IDC-P) is an aggressive subtype of prostate cancer characterized by the growth of tumor cells within the prostate ducts. It is often found alongside invasive carcinoma and is associated with poor prognosis. Understanding the molecular mechanisms driving IDC-P is crucial for improved diagnosis, prognosis, and treatment strategies. This review summarizes the molecular characteristics of IDC-P and their prognostic indications, comparing them to conventional prostate acinar adenocarcinoma, to gain insights into its unique behavior and identify potential therapeutic targets.© 2024 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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大类 | 2 区医学

小类 | 3 区肿瘤学

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第一作者机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

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通讯机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. [*1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.

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