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Multi-omics analyses uncover metabolic signatures and gene expression profiles of interstitial cystitis/bladder pain syndrome

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机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. [2]Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. [3]Laboratory of Dermatology, Sichuan University, Chengdu, China.

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关键词： interstitial cystitis/bladder pain syndrome metabolomic analysis molecular mechanisms multi‐omics analyses transcriptome sequencing

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We explore molecular and metabolic pathways involved in interstitial cystitis (IC) with integrating multi-omics analysis for identifying potential diagnostic and therapeutic targets.Mouse models of IC/bladder pain syndrome (BPS) were established by intraperitoneal injection of cyclophosphamide and bladder tissue samples were collected for metabolomics and transcriptome analysis.We found a total of 82 and 145 differential metabolites in positive ion modes and negative ion modes, respectively. Glycerophospholipid metabolism, choline metabolism in cancer, and nucleotide metabolism pathways were significantly enriched in the IC/BPS group. Transcriptome analysis demonstrated that 1069 upregulated genes and 1087 downregulated genes were detected. Importantly, the stronger enrichment for cell cycle pathway was observed in IC/BPS than that in normal bladder tissue, which may be involved in the process of bladder remodeling. Moreover, the inflammatory response and inflammatory factors related pathways were enriched in the IC/BPS group.Our findings provide critical directions for further exploration of the molecular pathology underlying IC/BPS.© 2024 Wiley Periodicals LLC.

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大类 | 3 区医学

小类 | 3 区泌尿学与肾脏学

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第一作者机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

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通讯机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. [*1]Department of Urology/ Institute of Urology, West China Hospital, Sichuan University, 88 South Keyuan Rd, Chengdu, 610041, China.

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