详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Multi-omics analyses uncover metabolic signatures and gene expression profiles of interstitial cystitis/bladder pain syndrome

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. [2]Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. [3]Laboratory of Dermatology, Sichuan University, Chengdu, China.

出处：

DOI：

ISSN：

关键词： interstitial cystitis/bladder pain syndrome metabolomic analysis molecular mechanisms multi‐omics analyses transcriptome sequencing

摘要：

We explore molecular and metabolic pathways involved in interstitial cystitis (IC) with integrating multi-omics analysis for identifying potential diagnostic and therapeutic targets.Mouse models of IC/bladder pain syndrome (BPS) were established by intraperitoneal injection of cyclophosphamide and bladder tissue samples were collected for metabolomics and transcriptome analysis.We found a total of 82 and 145 differential metabolites in positive ion modes and negative ion modes, respectively. Glycerophospholipid metabolism, choline metabolism in cancer, and nucleotide metabolism pathways were significantly enriched in the IC/BPS group. Transcriptome analysis demonstrated that 1069 upregulated genes and 1087 downregulated genes were detected. Importantly, the stronger enrichment for cell cycle pathway was observed in IC/BPS than that in normal bladder tissue, which may be involved in the process of bladder remodeling. Moreover, the inflammatory response and inflammatory factors related pathways were enriched in the IC/BPS group.Our findings provide critical directions for further exploration of the molecular pathology underlying IC/BPS.© 2024 Wiley Periodicals LLC.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区泌尿学与肾脏学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区泌尿学与肾脏学

第一作者：

第一作者机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. [*1]Department of Urology/ Institute of Urology, West China Hospital, Sichuan University, 88 South Keyuan Rd, Chengdu, 610041, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Molecular Characteristics of Choledochal Cysts in Children: Transcriptome Sequencing [2]Corrigendum: Molecular characteristics of choledochal cysts in children: transcriptome sequencing [3]Integrated multi-omics analyses reveal Jorunnamycin A as a novel suppressor for muscle-invasive bladder cancer by targeting FASN and TOP1 [4]Integrated multi-omics analyses revealed the association between rheumatoid arthritis and colorectal cancer: MYO9A as a shared gene signature and an immune-related therapeutic target [5]The multi-omics analyses of acsl1 reveal its translational significance as a tumor microenvironmental and prognostic biomarker in clear cell renal cell carcinoma [6]Integrated multi-omics analyses reveal that BCAM is associated with epigenetic modification and tumor microenvironment subtypes of clear cell renal cell carcinoma [7]Deep sequencing reveals a global reprogramming of lncRNA transcriptome during EMT [8]The genetic landscape of benign thyroid nodules revealed by whole exome and transcriptome sequencing. [9]Transcriptome sequencing identified hub genes for hepatocellular carcinoma by weighted-gene co-expression analysis. [10]The genetic landscape of benign thyroid nodules revealed by whole exome and transcriptome sequencing.