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Electroacupuncture alleviates ventilator-induced lung injury in mice by inhibiting the TLR4/NF-κB signaling pathway

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机构： [1]Department of Anesthesiology, The Second Clinical Medical College, Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People’s Hospital, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu 611137, Sichuan Province, China [2]Department of Anesthesiology, North Sichuan Medical College, Chengdu Fifth People’s Hospital, Chengdu 611137, Sichuan Province, China

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关键词： Electroacupuncture Mechanical ventilation Lung injury TLR4/NF- κB signaling

摘要：

This study was aimed to explore the protective effect of electroacupuncture (EA) pretreatment at Zusanli point (ST36) on ventilation-induced lung injury (VILI) and its potential anti-inflammatory mechanism.High tidal volume ventilation was used to induce the VILI in mice, and EA pretreatment at ST36 was given for 7 consecutive days. The wet/dry ratio and pathological injury score of lung tissue, and total protein content of pulmonary alveolar lavage fluid (BALF) were detected after 4 h of mechanical ventilation (MV). Meanwhile, the expressions of TLR4 and NF- κB in lung tissue were evaluated by Western Blot, and the inflammatory factors in lung tissue were detected by ELISA.After four hours of mechanical ventilation, mice with ventilator-induced lung injury showed significant increases in lung wet/dry ratio, tissue damage scores, and protein content in bronchoalveolar lavage fluid. Pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) and TLR4/NF-κB expression levels in the lung were also markedly elevated (P < 0.05). Conversely, ST36 acupuncture point pre-treatment significantly reduced these parameters (P < 0.05).EA pretreatment at ST36 could alleviate the inflammatory response for VILI via inhibiting TLR4/NF- κB pathway.© 2024. The Author(s).

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区麻醉学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区麻醉学

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第一作者机构： [1]Department of Anesthesiology, The Second Clinical Medical College, Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People’s Hospital, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu 611137, Sichuan Province, China

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Electroacupuncture alleviates ventilator-induced lung injury in mice by inhibiting the TLR4/NF-κB signaling pathway

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