Advanced Age May Not Be an Absolute Contraindication for Radical Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Center Case Series and a Systematic Review with Meta-Analyses
机构：[1]Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.四川大学华西医院[2]West China School of Medicine, Sichuan University, Chengdu 610041, China.四川大学华西医院
This study aims to investigate whether advanced age is an absolute contraindication for radical nephroureterectomy (RNU) in patients with upper tract urothelial carcinoma (UTUC) through a single-center case series and a systematic review with meta-analysis.In the single-center case series, 588 UTUC patients who underwent RNU between May 2003 and June 2019 in West China Hospital were enrolled, and cancer-specific survival (CSS) was the primary outcome of interest. In the systematic review with meta-analysis, PubMed, Scopus, Embase, and Cochrane databases were systematically searched for related articles for further analysis. The endpoints for meta-analyses were overall survival (OS) and CSS.The single-center case series included 57 (9.7%) octogenarians. The CSS of octogenarians after RNU was comparable to that of younger people. Advanced age (≥80) was not an independent risk factor for poor CSS (HR, 1.08; 95% CI, 0.48, 2.40). In a systematic review with meta-analysis, the cut-off value of advanced age is 70, and the results showed that advanced age was associated with inferior OS (pooled HR, 1.55; 95% CI, 1.29, 2.01) and CSS (pooled HR, 1.37; 95% CI, 1.08, 1.65). However, the subgroup analysis of countries found no positive correlation between advanced age and CSS (pooled HR, 1.33; 95% CI 0.92, 1.74) in Chinese.Advanced age may no longer be an absolute contraindication for RNU. RNU can be safely and effectively performed on UTUC patients of advanced age after a comprehensive presurgical evaluation.
基金：
This work was supported by the National Natural Science Foundation of China (Grant
number: 81500522) and the Science and Technology Department of Sichuan Province (Grant numbers:
2020YFS0090 and 2020YFS0046).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|3 区医学
小类|2 区医学：内科
最新[2023]版：
大类|3 区医学
小类|2 区医学：内科
第一作者：
第一作者机构：[1]Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.[2]West China School of Medicine, Sichuan University, Chengdu 610041, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Ye Jianjun,Wu Qiyou,Liao Xinyang,et al.Advanced Age May Not Be an Absolute Contraindication for Radical Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Center Case Series and a Systematic Review with Meta-Analyses[J].Journal Of Clinical Medicine.2023,12(23):doi:10.3390/jcm12237273.
APA：
Ye Jianjun,Wu Qiyou,Liao Xinyang,Zheng Lei,Wei Qiang&Bao Yige.(2023).Advanced Age May Not Be an Absolute Contraindication for Radical Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Center Case Series and a Systematic Review with Meta-Analyses.Journal Of Clinical Medicine,12,(23)
MLA：
Ye Jianjun,et al."Advanced Age May Not Be an Absolute Contraindication for Radical Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Center Case Series and a Systematic Review with Meta-Analyses".Journal Of Clinical Medicine 12..23(2023)
