详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Early, non-invasive detection of radiation-induced lung injury using PET/CT by targeting CXCR4

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China. [2]Department of PET/CT Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China. [3]Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

出处：

DOI：

ISSN：

关键词： Radiation-induced lung injury Molecular imaging PET/CT C-X-C-chemokine-receptor-type-4

摘要：

Radiation-induced lung injury (RILI) is a severe side effect of radiotherapy (RT) for thoracic malignancies and we currently lack established methods for the early detection of RILI. In this study, we synthesized a new tracer, [18F]AlF-NOTA-QHY-04, targeting C-X-C-chemokine-receptor-type-4 (CXCR4) and investigated its feasibility to detect RILI.An RILI rat model was constructed and scanned with [18F]AlF-NOTA-QHY-04 PET/CT and [18F]FDG PET/CT periodically after RT. Dynamic, blocking, autoradiography, and histopathological studies were performed on the day of peak uptake. Fourteen patients with radiation pneumonia, developed during or after thoracic RT, were subjected to PET scan using [18F]AlF-NOTA-QHY-04.The yield of [18F]AlF-NOTA-QHY-04 was 28.5-43.2%, and the specific activity was 27-33 GBq/μmol. [18F]AlF-NOTA-QHY-04 was mainly excreted through the kidney. Significant increased [18F]AlF-NOTA-QHY-04 uptake in the irradiated lung compared with that in the normal lung in the RILI model was observed on day 6 post-RT and peaked on day 14 post-RT, whereas no apparent uptake of [18F]FDG was shown on days 7 and 15 post-RT. MicroCT imaging did not show pneumonia until 42 days post-RT. Significant intense [18F]AlF-NOTA-QHY-04 uptake was confirmed by autoradiography. Immunofluorescence staining demonstrated expression of CXCR4 was significantly increased in the irradiated lung tissue, which correlated with results obtained from hematoxylin-eosin and Masson's trichrome staining. In 14 patients with radiation pneumonia, maximum standardized uptake values (SUVmax) were significantly higher in the irradiated lung compared with those in the normal lung. SUVmax of patients with grade 2 RILI was significantly higher than that of patients with grade 1 RILI.This study indicated that [18F]AlF-NOTA-QHY-04 PET/CT imaging can detect RILI non-invasively and earlier than [18F]FDG PET/CT in a rat model. Clinical studies verified its feasibility, suggesting the clinical potential of [18F]AlF-NOTA-QHY-04 as a PET/CT tracer for early monitoring of RILI.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 1 区

医学

小类 | 1 区核医学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区核医学

第一作者：

第一作者机构： [1]Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Gene-modified Mesenchymal Stem Cells Protect Against Radiation-induced Lung Injury [2]A retrospective study of 68Ga-FAPI PET/CT in differentiating the nature of pulmonary lesions [3]FAPI-04 PET/CT Using [F-18]AlF Labeling Strategy: Automatic Synthesis, Quality Control, and In Vivo Assessment in Patient [4](AlF)-F-18-NOTA-FAPI-04 Outperforms F-18-FDG PET/CT in Identifying the Primary Lesion and Rare Metastases From Gastric Cancer [5]在头颈部肿瘤放疗中PET-CT显示解剖生物靶区的应用进展 [6]Performance of [18F]FDG PET/CT versus FAPI PET/CT for lung cancer assessment: a systematic review and meta-analysis [7]Deep learning based time-to-event analysis with PET, CT and joint PET/CT for head and neck cancer prognosis [8]肺癌的早期筛查现状及进展 [9]一篇文章读懂pet/ct检查及注意事项 [10]Hepatic Lesion of Mucosa-Associated Lymphoid Tissue Lymphoma Revealed by Al18F-NOTA-FAPI-04 PET/CT.