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Early, non-invasive detection of radiation-induced lung injury using PET/CT by targeting CXCR4

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资源类型：
Pubmed体系：
作者：
Pei Jinli[1] * ; Cheng Kai[2] * ; Liu Tianxin[1,3] ; Gao Min[1] ; Wang Shijie[1] ; Xu Shengnan[1] ; Guo Yanluan[2] ; Ma Li[2] ; Li Wanhu[2] ; Wang Bolin[1,3] ; Yu Jinming[1] ; Liu Jie[1] ;
机构： [1]Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China. [2]Department of PET/CT Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China. [3]Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
出处：
DOI： 10.1007/s00259-023-06517-5
ISSN：

关键词： Radiation-induced lung injury Molecular imaging PET/CT C-X-C-chemokine-receptor-type-4

摘要：
Radiation-induced lung injury (RILI) is a severe side effect of radiotherapy (RT) for thoracic malignancies and we currently lack established methods for the early detection of RILI. In this study, we synthesized a new tracer, [18F]AlF-NOTA-QHY-04, targeting C-X-C-chemokine-receptor-type-4 (CXCR4) and investigated its feasibility to detect RILI.An RILI rat model was constructed and scanned with [18F]AlF-NOTA-QHY-04 PET/CT and [18F]FDG PET/CT periodically after RT. Dynamic, blocking, autoradiography, and histopathological studies were performed on the day of peak uptake. Fourteen patients with radiation pneumonia, developed during or after thoracic RT, were subjected to PET scan using [18F]AlF-NOTA-QHY-04.The yield of [18F]AlF-NOTA-QHY-04 was 28.5-43.2%, and the specific activity was 27-33 GBq/μmol. [18F]AlF-NOTA-QHY-04 was mainly excreted through the kidney. Significant increased [18F]AlF-NOTA-QHY-04 uptake in the irradiated lung compared with that in the normal lung in the RILI model was observed on day 6 post-RT and peaked on day 14 post-RT, whereas no apparent uptake of [18F]FDG was shown on days 7 and 15 post-RT. MicroCT imaging did not show pneumonia until 42 days post-RT. Significant intense [18F]AlF-NOTA-QHY-04 uptake was confirmed by autoradiography. Immunofluorescence staining demonstrated expression of CXCR4 was significantly increased in the irradiated lung tissue, which correlated with results obtained from hematoxylin-eosin and Masson's trichrome staining. In 14 patients with radiation pneumonia, maximum standardized uptake values (SUVmax) were significantly higher in the irradiated lung compared with those in the normal lung. SUVmax of patients with grade 2 RILI was significantly higher than that of patients with grade 1 RILI.This study indicated that [18F]AlF-NOTA-QHY-04 PET/CT imaging can detect RILI non-invasively and earlier than [18F]FDG PET/CT in a rat model. Clinical studies verified its feasibility, suggesting the clinical potential of [18F]AlF-NOTA-QHY-04 as a PET/CT tracer for early monitoring of RILI.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

基金：
The study was supported by funding from the Academic Promotion Program of Shandong First Medical University (2019ZL002), the Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences (2019RU071), the foundation of National Natural Science Foundation of China (81627901, 81972863, 82030082, and 82203014), the foundation of Natural Science Foundation of Shandong (ZR201911040452, ZR2019LZL018, ZR2020QH327, and ZR2022QH017), Taishan Scholars Program (NO.tsqn202306386) and the Youth Foundation Cultivation Project of Shandong First Medical University (202201–113).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 核医学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 核医学
第一作者：
第一作者机构： [1]Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Pei Jinli,Cheng Kai,Liu Tianxin,et al.Early, non-invasive detection of radiation-induced lung injury using PET/CT by targeting CXCR4[J].European Journal Of Nuclear Medicine And Molecular Imaging.2023,doi:10.1007/s00259-023-06517-5.
APA：
Pei Jinli,Cheng Kai,Liu Tianxin,Gao Min,Wang Shijie...&Liu Jie.(2023).Early, non-invasive detection of radiation-induced lung injury using PET/CT by targeting CXCR4.European Journal Of Nuclear Medicine And Molecular Imaging,,
MLA：
Pei Jinli,et al."Early, non-invasive detection of radiation-induced lung injury using PET/CT by targeting CXCR4".European Journal Of Nuclear Medicine And Molecular Imaging .(2023)

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