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Dosimetric comparison in sparing normal tissue dosage by using auto-SBRT planning in oligo liver tumors

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机构: [1]Head and Neck Oncology Department, Cancer Center, West China Hospital, Sichuan University, Chengdu, China. [2]Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China. [3]Cancer Center, West China Hospital, Sichuan University, Chengdu, China. [4]West China Clinical Skills Training Center, West China School of Medicine/West China Hospital, Sichuan University, Chengdu, China. [5]Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China. [6]Radiotherapy Physics and Technology Center, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
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关键词: liver cancer dose sparing stereotactic body radiation therapy volumetric-modulated arc therapy auto-planning number of half arcs

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The study aimed to compare the dosimetric distribution of VMAT plans by increasing the number of half arcs in liver SBRT and investigate the effect by using automatic plan software in plan optimization.Thirty-one patients with oligo liver tumors were randomly selected. VMAT treatment plans with different numbers of coplanar half arcs were generated.Adding arcs significantly increased the PTV, D2%, D50%, and CI, but sacrificed the plan homogeneity. It also decreased the maximum dose of normal tissues such as the stomach, duodenum, and spinal cord and reduced Dmean, D500cc, and D700cc for the liver. Nevertheless, the diminishing effect gradually decayed into three arcs. Meanwhile, the addition of arcs substantially extended the beam-on time.In the context of SBRT for oligo liver tumors, increasing the number of coplanar half arcs will improve PTV conformity and offer better protection for OARs, albeit at the expense of increased treatment duration. Considering the trade-off between plan quality and treatment efficiency, a three-arc plan may be more suitable for clinical implementation.Copyright © 2023 Zhang, Zhan, Zeng, Yang, Xiong, Liao, Chen and Xiao.

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出版当年[2023]版:
大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 肿瘤学
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出版当年[2023]版:
Q2 ONCOLOGY
最新[2023]版:
Q2 ONCOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

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第一作者机构: [1]Head and Neck Oncology Department, Cancer Center, West China Hospital, Sichuan University, Chengdu, China. [2]Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
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