机构：[1]Department of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, 610041, China.四川大学华西医院[2]Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, China.四川大学华西医院[3]Animal Experimental Center, West China Hospital, Sichuan University, Chengdu, 610041, China.四川大学华西医院[4]Core facility of West China Hospital, Sichuan University, Chengdu, 610041, China.四川大学华西医院[5]WestChina-California Research Center for Predictive Intervention Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.四川大学华西医院[6]Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, 2145, Australia.
Alveolar bone injury under diabetic conditions can severely impede many oral disease treatments. Rebuilding diabetic alveolar bone in clinics is currently challenging due to persistent infection and inflammatory response. Here, we develop an antibacterial DNA-based hydrogel named Agantigel by integrating silver nanoclusters (AgNCs) and tumor necrosis factor-alpha (TNF-α) antibody into DNA hydrogel to promote diabetic alveolar bone regeneration. Agantigel can effectively inhibit bacterial growth through AgNCs while exhibiting negligible cytotoxicity in vitro. The sustained release of TNF-α antibody from Agantigel effectively blocks TNF-α and promotes M2 polarization of macrophages, ultimately accelerating diabetic alveolar bone regeneration in vivo. After 21 days of treatment, Agantigel significantly accelerates the defect healing rate of diabetic alveolar bone up to 82.58 ± 8.58% and improves trabecular architectures compared to free TNF-α (42.52 ± 15.85%). Our results imply that DNA hydrogels are potential bio-scaffolds helping the sustained release of multidrug for treating DABI or other oral diseases. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
基金：
This work was financially supported by the National Natural Science Foundation of China
(82070660), Clinical Research Incubation Project, West China Hospital of Sichuan
University (2021HXFH009), China Postdoctoral Science Foundation (2021TQ0225,
2021M702370), the Sichuan University Postdoctoral Interdisciplinary Innovation Fund, the
Post-Doctor Research Project, West China Hospital of Sichuan University (2021HXBH065),
Program of Natural Science Foundation of Sichuan (2022NSFSC1569, 2022NSFSC1559).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|3 区化学
小类|3 区高分子科学
最新[2023]版：
大类|3 区化学
小类|3 区高分子科学
第一作者：
第一作者机构：[1]Department of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, 610041, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Peng Linrui,Li Wei,Peng Ge,et al.Antibacterial and DNA-Based Hydrogels in Situ Block TNF-α to Promote Diabetic Alveolar Bone Rebuilding[J].Macromolecular rapid communications.2023,e2300559.doi:10.1002/marc.202300559.
APA：
Peng Linrui,Li Wei,Peng Ge,Wei Danfeng,Gou Liping...&Zhang Yuwei.(2023).Antibacterial and DNA-Based Hydrogels in Situ Block TNF-α to Promote Diabetic Alveolar Bone Rebuilding.Macromolecular rapid communications,,
MLA：
Peng Linrui,et al."Antibacterial and DNA-Based Hydrogels in Situ Block TNF-α to Promote Diabetic Alveolar Bone Rebuilding".Macromolecular rapid communications .(2023):e2300559
