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Physically Cross-Linked DNA Hydrogel-Based Sustained Cytokine Delivery for In Situ Diabetic Alveolar Bone Rebuilding.

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WOS体系：
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收录情况： ◇ SCIE

作者：
Li Wei[1] ; Wang Chengshi[1] ; Wang Zhenghao[1,2] ; Gou Liping[1] ; Zhou Ye[1] ; Peng Ge[1] ; Zhu Min[1,3] ; Zhang Jiayi[1] ; Li Ruoqing[1,4] ; Ni Hengfan[5] ; Wu Lei[6] ; Zhang Wanli[6] ; Liu Jiaye[7] ; Tian Yali[8] ; Chen Zhong[9] ; Han Yuan-Ping[10] ; Tong Nanwei[1] ; Fu Xianghui[11] ; Zheng Xiaofeng[1] ; Berggren Per-Olof[1,2] ;
机构： [1]Department of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu 610041, China. [2]The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-17176 Stockholm, Sweden. [3]Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. [4]Department of General Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing 400014, China. [5]Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China. [6]Core Facility of West China Hospital, Sichuan University, Chengdu 610041, China. [7]Department of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. [8]West China School of Nursing, West China Hospital, Sichuan University, Chengdu 610041, China. [9]Department of Spinal Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. [10]The Center for Growth, Metabolism and Aging, The College of Life Sciences, Sichuan University, Chengdu 610065, China. [11]Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
出处：
DOI： 10.1021/acsami.2c04769
ISSN：

摘要：
The development of a biodegradable and shape-adaptable bioscaffold that can enhance local cytokine retention and bioactivity is essential for the application of immunotherapy in periodontal diseases. Here, we report a biodegradable, anti-inflammatory, and osteogenic ILGel that uses a physically cross-linked DNA hydrogel as a soft bioscaffold for the long-term sustained release of cytokine interleukin-10 (IL-10) to accelerate diabetic alveolar bone rebuilding. Porous microstructures of ILGel favored the encapsulation of IL-10 and maintained IL-10 bioactivity for at least 7 days. ILGel can be gradually degraded or hydrolyzed under physiological conditions, avoiding the potential undesired side effects on dental tissues. Long-term sustained release of bioactive IL-10 from ILGel not only promoted M2 macrophage polarization and attenuated periodontal inflammation but also triggered osteogenesis of mesenchymal stem cells (MSCs), leading to accelerated alveolar bone formation and healing of alveolar bone defects under diabetic conditions in vivo. ILGel treatment significantly accelerated the defect healing rate of diabetic alveolar injury up to 93.42 ± 4.6% on day 21 post treatment compared to that of free IL-10 treatment (63.30 ± 7.39%), with improved trabecular architectures. Our findings imply the potential application of the DNA hydrogel as the bioscaffold for cytokine-based immunotherapy in diabetic alveolar bone injury and other periodontal diseases.

基金：
This study was supported by the National Natural Science Foundation of China (81801589, 82070846), the Center of Excellence-International Collaboration Initiative Grant of West China Hospital (139180012), the Program for Overseas High- Level Talents Introduction of Sichuan Province of China (21RCYJ0046), the China Postdoctoral Science Foundation (2018M643487, 2021TQ0225, 2021M702370), the Post- Doctor Research Project, West China Hospital of Sichuan University (2021HXBH065, 2019HXBH027), a Grant from Technology Innovation R & D Project of Chengdu Science and Technology Bureau (2019-YF05-01243-SN), and the 1.3.5 project for disciplines of excellence, West China Hospital of Sichuan University (ZYGD18017).
语种：
外文
被引次数：
WOS：
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 材料科学
小类 | 2 区 纳米科技 2 区 材料科学：综合
最新[2023]版：
大类 | 2 区 材料科学
小类 | 2 区 材料科学：综合 2 区 纳米科技
JCR分区：
出版当年[2022]版：
Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY
最新[2023]版：
Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu 610041, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Wei,Wang Chengshi,Wang Zhenghao,et al.Physically Cross-Linked DNA Hydrogel-Based Sustained Cytokine Delivery for In Situ Diabetic Alveolar Bone Rebuilding.[J].ACS APPLIED MATERIALS & INTERFACES.2022,14(22):25173-25182.doi:10.1021/acsami.2c04769.
APA：
Li Wei,Wang Chengshi,Wang Zhenghao,Gou Liping,Zhou Ye...&Berggren Per-Olof.(2022).Physically Cross-Linked DNA Hydrogel-Based Sustained Cytokine Delivery for In Situ Diabetic Alveolar Bone Rebuilding..ACS APPLIED MATERIALS & INTERFACES,14,(22)
MLA：
Li Wei,et al."Physically Cross-Linked DNA Hydrogel-Based Sustained Cytokine Delivery for In Situ Diabetic Alveolar Bone Rebuilding.".ACS APPLIED MATERIALS & INTERFACES 14..22(2022):25173-25182

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