详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Genomic alterations and diagnosis of renal cancer

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Pathology and Molecular Pathology, University Hospital Zurich, Schmelzbergstr. 12, 8091, Zurich, Switzerland. [2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. [3]Faculty of Medicine, University of Zurich, Zurich, Switzerland.

出处：

DOI：

ISSN：

关键词： Genomic alterations Diagnostic value Kidney cancer Renal cell carcinoma Molecular defined entities

摘要：

The application of molecular profiling has made substantial impact on the classification of urogenital tumors. Therefore, the 2022 World Health Organization incorporated the concept of molecularly defined renal tumor entities into its classification, including succinate dehydrogenase-deficient renal cell carcinoma (RCC), FH-deficient RCC, TFE3-rearranged RCC, TFEB-altered RCC, ALK-rearranged RCC, ELOC-mutated RCC, and renal medullary RCC, which are characterized by SMARCB1-deficiency. This review aims to provide an overview of the most important molecular alterations in renal cancer, with a specific focus on the diagnostic value of characteristic genomic aberrations, their chromosomal localization, and associations with renal tumor subtypes. It may not yet be the time to completely shift to a molecular RCC classification, but undoubtedly, the application of molecular profiling will enhance the accuracy of renal cancer diagnosis, and ultimately guide personalized treatment strategies for patients.© 2023. The Author(s).

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 3 区医学

小类 | 2 区病理学

最新[2023]版：

大类 | 3 区医学

小类 | 2 区病理学

第一作者：

第一作者机构： [1]Department of Pathology and Molecular Pathology, University Hospital Zurich, Schmelzbergstr. 12, 8091, Zurich, Switzerland. [2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

通讯作者：

通讯机构： [1]Department of Pathology and Molecular Pathology, University Hospital Zurich, Schmelzbergstr. 12, 8091, Zurich, Switzerland. [3]Faculty of Medicine, University of Zurich, Zurich, Switzerland.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Identification of a novel 5-methylcytosine-related signature for prognostic prediction of kidney renal papillary cell carcinoma and a Putative target for drug repurposing [2]BAP1-Related ceRNA (NEAT1/miR-10a-5p/SERPINE1) Promotes Proliferation and Migration of Kidney Cancer Cells. [3]Knockdown of ribosomal protein S15A inhibits human kidney cancer cell growth in vitro and in vivo. [4]Lymph Node Density as an Independent Prognostic Factor in Node-Positive Renal-Cell Carcinoma: Results From the Surveillance, Epidemiology, and End Results Program. [5]Mammalian SWI/SNF Complex Genomic Alterations and Immune Checkpoint Blockade in Solid Tumors. [6]Cancer Genomic Alterations Can Be Potential Biomarkers Predicting Microvascular Invasion and Early Recurrence of Hepatocellular Carcinoma. [7]Mir-451 Correlates with Prognosis of Renal Cell Carcinoma Patients and Inhibits Cellular Proliferation of Renal Cell Carcinoma [8]Hypomethylation of MAGE-A1 in clear cell renal cell carcinoma [9]Tumor microenvironment characterization in head and neck squamous carcinoma reveals distinct genomic alterations and clinical outcomes [10]Characteristics of genomic alterations of lung adenocarcinoma in young never-smokers.