机构：[1]Academician Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong, P. R. China.[2]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, P. R. China.[3]Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, P. R. China.[4]Department of Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, P. R. China.[5]Department of Infectious Diseases, Affiliated Hospital of North Sichuan Medical College, Nanchong, P. R. China.[6]Center of Materials Science and Optoelectronics Engineering, College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing, P. R. China.[7]CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing, P. R. China.[8]Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, P. R. China.
Lead halide perovskites (LHPs) are outstanding candidates for next-generation optoelectronic materials, with considerable prospects of use and commercial value. However, knowledge about their toxicity is scarce, which may limit their commercialization. Here, for the first time, we studied the cardiotoxicity and molecular mechanisms of representative CsPbBr3 nanoparticles in LHPs. After their intranasal administration to Institute of Cancer Research (ICR) mice, using advanced synchrotron radiation, mass spectrometry, and ultrasound imaging, we revealed that CsPbBr3 nanoparticles can severely affect cardiac systolic function by accumulating in the myocardial tissue. RNA sequencing and Western blotting demonstrated that CsPbBr3 nanoparticles induced excessive oxidative stress in cardiomyocytes, thereby provoking endoplasmic reticulum stress, disturbing calcium homeostasis, and ultimately leading to apoptosis. Our findings highlight the cardiotoxic effects of LHPs and provide crucial toxicological data for the product.
基金：
National Key R&D Program
of China (No. 2021YFA1201200 and 2020YFA0710702);
Strategic Priority Research Program of Chinese Academy of
Sciences (No. XDB36000000); Directional Institutionalized
Scientific Research Platform relies on Beijing Synchrotron
Radiation Facility of Chinese Academy of Sciences; Beijing
Natural Science Foundation (No. 2222087); Science and Technology Project of Nanchong (No. 20SXQT0022 and
22SXQT0364); Science and Technology Department of
Sichuan Province Project (No. 2021YJ0208); and Research
Project Foundation of Affiliated Hospital of North Sichuan
Medical College (No. 2022JB002).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|3 区医学
小类|2 区毒理学3 区纳米科技
最新[2023]版：
大类|3 区医学
小类|2 区毒理学3 区纳米科技
第一作者：
第一作者机构：[1]Academician Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong, P. R. China.[2]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, P. R. China.[3]Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, P. R. China.
共同第一作者：
通讯作者：
通讯机构：[1]Academician Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong, P. R. China.[2]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, P. R. China.[6]Center of Materials Science and Optoelectronics Engineering, College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing, P. R. China.[8]Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, P. R. China.[*1]Academician Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong, P. R. China
推荐引用方式(GB/T 7714)：
He Rendong,Ding Xuefeng,Zhang Tingjun,et al.Study on myocardial toxicity induced by lead halide perovskites nanoparticles[J].Nanotoxicology.2023,1-22.doi:10.1080/17435390.2023.2255269.
APA：
He Rendong,Ding Xuefeng,Zhang Tingjun,Mei Linqiang,Zhu Shuang...&Hu Houxiang.(2023).Study on myocardial toxicity induced by lead halide perovskites nanoparticles.Nanotoxicology,,
MLA：
He Rendong,et al."Study on myocardial toxicity induced by lead halide perovskites nanoparticles".Nanotoxicology .(2023):1-22
