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Notopterol alleviates the progression of osteoarthritis: An in vitro and in vivo study

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资源类型：
Pubmed体系：
作者：
Qu Yuhan[1,2] * ; Qiu Lu[1,4] ; Qiu Hui[1] ; Shen Yue[1] ; Tang Min[1] ; Huang Yuehui[1] ; Peng Yi[1] ; Wang Jun[3] ; Fu Qiang[1] ;
机构： [1]Key Laboratory of Drug-Targeting and Drug Delivery System of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China [2]School of Food and Biological engineering, Chengdu University, Chengdu 610106, China [3]Department of Pharmacy, Chengdu Integrated TCM and Western Medicine Hospital, Chengdu 610041, China [4]School of Chemical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China
出处：
DOI： 10.1016/j.cyto.2023.156309
ISSN：

关键词： Osteoarthritis Notopterol C28/I2 cells Inflammation Apoptosis vivo

摘要：
Osteoarthritis (OA) is a prevalent degenerative joint disorder caused by the progressive destruction of cartilage and inflammation in the articular cavity. Studies have proved that the inhibition of articular cartilage destruction and generation of inflammatory factors can be effective strategies for treating OA. Notopterol (NOT) is a quality control index of Notopterygium incisum Ting ex H. T. Chang (N. incisum) with anti-inflammatory, antioxidant, and analgesic activities. Moreover, NOT has been used for many years to treat joint diseases. A study using human C28/I2 cells suggested that NOT down-regulated the hypersecretion of inflammatory mediators and alleviated the degradation of the extracellular matrix (ECM). In addition, NOT decreased the overproduction of reactive oxygen species (ROS) and chondrocyte apoptosis through the nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway. NOT exerted a chondroprotective effect by partly inhibiting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) and phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signaling pathways and regulating the nuclear factor Nrf2/heme oxygenase-1(HO-1) signaling pathway. In vivo, NOT improved the destruction of articular cartilage in a rat OA model, which may be related to the inhibition of tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6, and IL-12 expressions in synovial fluid. In summary, these results showed that NOT alleviated the progression of OA and is expected to become a new therapy for treating OA clinically.Copyright © 2023 Elsevier Ltd. All rights reserved.

基金：
This study is supported by the Natural Science Foundation of China (NSFC, No. 81872971), Key R&D Program of Science and Technology Bureau of Chengdu (2019-YFYF-00002-SN), and Application and Foundation Research Projects of Sichuan Province (2021YJ0116).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 生化与分子生物学 3 区 细胞生物学 3 区 免疫学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 生化与分子生物学 3 区 细胞生物学 3 区 免疫学
第一作者：
第一作者机构： [1]Key Laboratory of Drug-Targeting and Drug Delivery System of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China [2]School of Food and Biological engineering, Chengdu University, Chengdu 610106, China
通讯作者：
通讯机构： [1]Key Laboratory of Drug-Targeting and Drug Delivery System of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China [4]School of Chemical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China
推荐引用方式(GB/T 7714)：
Qu Yuhan,Qiu Lu,Qiu Hui,et al.Notopterol alleviates the progression of osteoarthritis: An in vitro and in vivo study[J].Cytokine.2023,169:156309.doi:10.1016/j.cyto.2023.156309.
APA：
Qu Yuhan,Qiu Lu,Qiu Hui,Shen Yue,Tang Min...&Fu Qiang.(2023).Notopterol alleviates the progression of osteoarthritis: An in vitro and in vivo study.Cytokine,169,
MLA：
Qu Yuhan,et al."Notopterol alleviates the progression of osteoarthritis: An in vitro and in vivo study".Cytokine 169.(2023):156309

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