Partial preservation of the normal thyroid gland based on tumor diameter may be possible in small medullary thyroid carcinoma: a two-center 15-year retrospective study
BackgroundAt present, there are some controversies in the formulation of surgical protocol for small medullary thyroid carcinoma(s-MTC). We wanted to explore the feasibility of normal thyroid gland retention in small medullary thyroid carcinoma based on different tumor diameters and its prognostic impact on the tumor. MethodsThe data of patients with stage T1 MTC treated at Tianjin Cancer Hospital and Sichuan Cancer Hospital from 2006 to 2021 were analyzed. The tumor diameters of 0.5 cm and 1.0 cm were used as dividing points. The outcomes were tumor recurrence, metastasis, or patient death. Survival was estimated by the Kapan-Meier curve. ResultsA total of 121 T1 s-MTC patients were included, including 55 with total thyroidectomy (TT) and 66 with subthyroidectomy (Sub-TT). There were eleven cases of tumor recurrence and metastasis, and four patients died. When the tumor diameter was 1.0 cm as the cut-off point, tumor diameter (p = 0.010), TT (p = 0.028), unilateral and bilateral type (p = 0.009), and TNM staging (p = 0.007) had significant effects on progression-free survival (PFS). The tumor diameter, unilateral and bilateral type, and TT were risk factors for the prognosis of T1 MTC (p < 0.05). ConclusionThe tumor diameter of 1.0 cm can be used as a cut-off point for stage T1 MTC. Alt-hough there was no significant difference in overall survival (OS) between T1a and T1b in patients, tumor diameter significantly influenced PFS. TT is not necessary for patients with sporadic MTC with T1a.
基金：
National Natural Science Foundation of China [82172821, 82103386, 82272721]; Tianjin Municipal Science and Technology Project [19JCYBJC27400, 21JCZDJC00360]; Beijing-Tianjin-Hebei Basic Research Cooperation Project [20JCZXJC00120]; Science and Technology Development Fund of the Tianjin Education Commission for Higher Education [2021ZD033]; Tianjin Medical Key Discipline (Specialty) Construction Project [TJYXZDXK-058B]; Tianjin Health Research Project [TJWJ2022XK024]
第一作者机构：[1]Tianjin Med Univ Canc Inst & Hosp, Dept Thyroid & Neck Tumor, Natl Clin Res Ctr Canc, Tianjins Clin Res Ctr Canc,Key Lab Canc Prevent &, Tianjin, Peoples R China[2]Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Affiliated Canc Hosp, Sichuan Clin Res Ctr Canc,Thyroid Otolaryngol Dept, Chengdu, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Tianjin Med Univ Canc Inst & Hosp, Dept Thyroid & Neck Tumor, Natl Clin Res Ctr Canc, Tianjins Clin Res Ctr Canc,Key Lab Canc Prevent &, Tianjin, Peoples R China[8]Tianjin Union Med Ctr, Dept Thyroid & Breast Surg, Tianjin, Peoples R China[9]Tianjin Union Med Ctr, Tianjin Key Lab Gen Surg Construct, Tianjin, Peoples R China
推荐引用方式(GB/T 7714)：
Fu Guiming,Li Xiaoyi,Guo Fengli,et al.Partial preservation of the normal thyroid gland based on tumor diameter may be possible in small medullary thyroid carcinoma: a two-center 15-year retrospective study[J].FRONTIERS IN ONCOLOGY.2023,13:doi:10.3389/fonc.2023.1216394.
APA：
Fu, Guiming,Li, Xiaoyi,Guo, Fengli,Ruan, Xianhui,Zhang, Wei...&Gao, Ming.(2023).Partial preservation of the normal thyroid gland based on tumor diameter may be possible in small medullary thyroid carcinoma: a two-center 15-year retrospective study.FRONTIERS IN ONCOLOGY,13,
MLA：
Fu, Guiming,et al."Partial preservation of the normal thyroid gland based on tumor diameter may be possible in small medullary thyroid carcinoma: a two-center 15-year retrospective study".FRONTIERS IN ONCOLOGY 13.(2023)
