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Lychee Seed Fraction (LSF) Suppressed A beta 1-42-induced Neuroinflammation, Apoptosis and Facilitated Viabilities of PC12 Cells via NF-kappa B Signalling Pathway

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收录情况： ◇ SCIE

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机构： [1]Zhejiang Chinese Med Univ Hangzhou, Zhejiang, Peoples R China [2]Yongjia Cty Peoples Hosp, Dept Tradit Chinese Med, Wenzhou, Zhejiang, Peoples R China [3]Yongjia Cty Peoples Hosp, Dept Acupuncture Moxibust & Rehabil, Wenzhou, Zhejiang, Peoples R China [4]Univ Elect Sci & Technol China Chengdu, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr, Sch Med, Sichuan 610041, Peoples R China

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关键词： Alzheimer's Disease Beta-Amyloid1-42 Inflammation Lychee Seed Fraction Nuclear Factor Kappa-B

摘要：

Traditional Chinese medicines have been widely used for Alzheimer's disease (AD) treatment. This study examined impacts of lychee seed fraction (LSF) on modulating PC12 cell apoptosis, viability and inflammatory responses after A beta 1-42 induction. CCK-8 was applied to measure PC12 cell viabilities, showing that A beta 1-42-induced low PC12 cell viabilities were promoted by LSF treatment dose-dependently. Moreover, using JC-1 staining, mitochondrial membrane potential (MMP) was suppressed with A beta 1-42 induction while LSF treatment reversed impacts of A beta 1-42. LSF also suppressed A beta 1-42-induced elevated TNF-alpha, IL-1 beta and iNOS mRNA and protein expressions. Additionally, LSF treatment restrained A beta 1-42-induced apoptosis through downregulating cleaved-PARP and Bax protein expressions and upregulating Bcl-2 protein expressions. Furthermore, LSF also downregulated I kappa B alpha and phosphorylated p65 protein expressions in PC12 cells after A beta 1-42 induction. Hence, LSF restrained A beta 1-42-induced low PC12 cell viability and high apoptosis through suppressing Bax and cleaved-PARP and elevating Bcl-2 via NF-kappa B signalling pathway.

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出版当年[2022]版：

大类 | 4 区生物学

小类 | 4 区遗传学

最新[2023]版：

大类 | 4 区生物学

小类 | 4 区遗传学

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出版当年[2022]版：

Q4 GENETICS & HEREDITY

最新[2023]版：

Q4 GENETICS & HEREDITY

影响因子： 0 最新[2023版] 0 最新五年平均 0.1 出版当年[2022版] 0.1 出版当年五年平均 0.205 出版前一年[2021版]

第一作者：

第一作者机构： [1]Zhejiang Chinese Med Univ Hangzhou, Zhejiang, Peoples R China [2]Yongjia Cty Peoples Hosp, Dept Tradit Chinese Med, Wenzhou, Zhejiang, Peoples R China

通讯作者：

通讯机构： [1]Zhejiang Chinese Med Univ Hangzhou, Zhejiang, Peoples R China [2]Yongjia Cty Peoples Hosp, Dept Tradit Chinese Med, Wenzhou, Zhejiang, Peoples R China

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