机构：[1]Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province, 310003, P.R. China.浙江大学医学院附属第一医院[2]College of Energy Engineering and State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou, 310027, China.[3]Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.[4]The First Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, 310027, China.浙江大学医学院附属第一医院[5]Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.[6]Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, China.[7]MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.[8]Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, China.[9]College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, China.[10]Jinhua Institute of Zhejiang University, Jinhua, 321299, China.[11]Department of General Surgery, Sir Run Run Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
The combination of ferroptosis inducers and immune checkpoint blockade (ICB) can enhance antitumor effects. However, the efficacy in tumors with low immunogenicity requires further investigation. Herein, we have developed a water-in-oil Pickering emulsion gel to deliver (1S, 3R)-RSL-3 (RSL-3), a ferroptosis inducer dissolved in iodized oil and programmed death-1 (PD-1) antibody, the most commonly used immune checkpoint inhibitor dissolved in water, with optimal characteristics (RSL-3+PD-1@gel). Tumor lipase degrades the continuous oil phase, which results in the slow release of RSL-3 and PD-1 antibody and a notable antitumor effect against low-immunogenic hepatocellular carcinoma (HCC) and pancreatic cancer. Intriguingly, the RSL-3+PD-1@gel induces ferroptosis of tumor cells, resulting in antitumor immune response via accumulation of helper T lymphocyte cells and cytotoxic T cells. Additionally, the single cell sequence profiling analysis during tumor treatment reveals the induction of ferroptosis in tumor cells together with strong antitumor immune response in ascites. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
基金：
National Natural Science Foundation of China
(Grant No. 82102817, 82074208, 82101830, 81602128, 21878258, and 52173142), the
Zhejiang Natural Science Foundation (Grant No. LQ22H160041, LY20H160033,
Y23H160106, and Y20B060027), the National Key R&D Program of China
(2021YFA0909900), the Scientific Research Fund of Zhejiang University (XY2022049) and
the Startup Package of Zhejiang University. C.-X. Zhao acknowledges the financial support
from ARC Discovery Project (DP200101238, DP210103079), and NHMRC Investigator
Grant APP2008698.
第一作者机构：[1]Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province, 310003, P.R. China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province, 310003, P.R. China.[2]College of Energy Engineering and State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou, 310027, China.[5]Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.[6]Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, China.[7]MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.[10]Jinhua Institute of Zhejiang University, Jinhua, 321299, China.[11]Department of General Surgery, Sir Run Run Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
推荐引用方式(GB/T 7714)：
Dai Xiaomeng,Zhang Jia,Bao Xuanwen,et al.Induction of Tumor Ferroptosis-Dependent Immunity via an Injectable Attractive Pickering Emulsion Gel[J].ADVANCED MATERIALS.2023,35(35):doi:10.1002/adma.202303542.
APA：
Dai Xiaomeng,Zhang Jia,Bao Xuanwen,Guo Yixuan,Jin Yuzhi...&Zhao Peng.(2023).Induction of Tumor Ferroptosis-Dependent Immunity via an Injectable Attractive Pickering Emulsion Gel.ADVANCED MATERIALS,35,(35)
MLA：
Dai Xiaomeng,et al."Induction of Tumor Ferroptosis-Dependent Immunity via an Injectable Attractive Pickering Emulsion Gel".ADVANCED MATERIALS 35..35(2023)
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