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Preoperative diagnosis of solitary pulmonary nodules with a novel hematological index model based on circulating tumor cells

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收录情况： ◇ SCIE

作者：
Zhou Qiuxi[1] ; He Qiao[2] ; Peng Ling[1] ; Huang Yecai[3] ; Li Kexun[4] ; Liu Kun[4] ; Li Da[1] ; Zhao Jing[1] ; Sun Kairong[5] ; Li Aoshuang[6] ; He Wenwu[4] ;
机构： [1]Department of General Internal Medicine, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Cancer Hospital Affiliated to University of Electronic Science and Technology of China, Chengdu, China. [2]Department of Clinical Laboratory, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Cancer Hospital Affiliated to University of Electronic Science and Technology of China, Chengdu, China. [3]Department of Radiation Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Cancer Hospital Affiliated to University of Electronic Science and Technology of China, Chengdu, China. [4]Department of Thoracic Surgery, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Cancer Hospital Affiliated to University of Electronic Science and Technology of China, Chengdu, China. [5]Department of Respiratory Medicine, Sichuan Academy Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, China. [6]Department of Gastroenterology, Chengdu Third People's Hospital, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.
出处：
DOI： 10.3389/fonc.2023.1150539
ISSN：

关键词： pulmonary nodules diagnosis biomarkers hematological index model nomogram

摘要：
Preoperative noninvasive diagnosis of the benign or malignant solitary pulmonary nodule (SPN) is still important and difficult for clinical decisions and treatment. This study aimed to assist in the preoperative diagnosis of benign or malignant SPN using blood biomarkers.A total of 286 patients were recruited for this study. The serum FR+CTC, TK1, TP, TPS, ALB, Pre-ALB, ProGRP, CYFRA21-1, NSE, CA50, CA199, and CA242 were detected and analyzed.In the univariate analysis, age, FR+CTC, TK1, CA50, CA19.9, CA242, ProGRP, NSE, CYFRA21-1, and TPS showed the statistical significance of a correlation with malignant SPNs (P <0.05). The highest performing biomarker is FR+CTC (odd ratio [OR], 4.47; 95% CI: 2.57-7.89; P <0.001). The multivariate analysis identified that age (OR, 2.69; 95% CI: 1.34-5.59, P = 0.006), FR+CTC (OR, 6.26; 95% CI: 3.09-13.37, P <0.001), TK1 (OR, 4.82; 95% CI: 2.4-10.27, P <0.001), and NSE (OR, 2.06; 95% CI: 1.07-4.06, P = 0.033) are independent predictors. A prediction model based on age, FR+CTC, TK1, CA50, CA242, ProGRP, NSE, and TPS was developed and presented as a nomogram, with a sensitivity of 71.1% and a specificity of 81.3%, and the AUC was 0.826 (95% CI: 0.768-0.884).The novel prediction model based on FR+CTC showed much stronger performance than any single biomarker, and it can assist in predicting benign or malignant SPNs.Copyright © 2023 Zhou, He, Peng, Huang, Li, Liu, Li, Zhao, Sun, Li and He.

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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学
JCR分区：
出版当年[2023]版：
Q2 ONCOLOGY
最新[2023]版：
Q2 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of General Internal Medicine, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Cancer Hospital Affiliated to University of Electronic Science and Technology of China, Chengdu, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhou Qiuxi,He Qiao,Peng Ling,et al.Preoperative diagnosis of solitary pulmonary nodules with a novel hematological index model based on circulating tumor cells[J].FRONTIERS IN ONCOLOGY.2023,13:doi:10.3389/fonc.2023.1150539.
APA：
Zhou Qiuxi,He Qiao,Peng Ling,Huang Yecai,Li Kexun...&He Wenwu.(2023).Preoperative diagnosis of solitary pulmonary nodules with a novel hematological index model based on circulating tumor cells.FRONTIERS IN ONCOLOGY,13,
MLA：
Zhou Qiuxi,et al."Preoperative diagnosis of solitary pulmonary nodules with a novel hematological index model based on circulating tumor cells".FRONTIERS IN ONCOLOGY 13.(2023)

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