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Hypertensive conditions of pregnancy, preterm birth, and premenopausal breast cancer risk: a premenopausal breast cancer collaborative group analysis

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机构: [1]Department of Epidemiology, Hazel B. Nichols, University of North Carolina at Chapel Hill Gillings School of Global Public Health, 2104F McGavran-Greenberg Hall, 135 Dauer Drive, Chapel Hill, Chapel Hill, NC 27599‑7435, USA [2]Westat, USA [3]Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, USA [4]Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, USA [5]Slone Epidemiology Center, Boston University, Boston, USA [6]Channing Division of Network Medicine, Department of Medicine Brigham and Women’s Hospital and Harvard Medical School, Boston, USA [7]Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA [8]Cancer Epidemiology Division Cancer Council Victoria, Melbourne, Australia [9]Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia [10]Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia [11]Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK [12]Boston University Chobanian & Avedisian School of Medicine, Boston University, Boston, USA [13]Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Solna, Sweden [14]Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, USA [15]Seaver Autism Center for Research and Treatment at Mount Sinai Icahn School of Medicine at Mount Sinai, New York, USA [16]Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, USA [17]Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China [18]Division of Breast Cancer Research, The Institute of Cancer Research, London, UK [19]Real World Solutions IQVIA, Amsterdam, The Netherlands
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关键词: Epidemiology Breast cancer Cohort

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Women with preeclampsia are more likely to deliver preterm. Reports of inverse associations between preeclampsia and breast cancer risk, and positive associations between preterm birth and breast cancer risk are difficult to reconcile. We investigated the co-occurrence of preeclampsia/gestational hypertension with preterm birth and breast cancer risk using data from the Premenopausal Breast Cancer Collaborative Group.Across 6 cohorts, 3096 premenopausal breast cancers were diagnosed among 184,866 parous women. We estimated multivariable hazard ratios (HR) and 95% confidence intervals (CI) for premenopausal breast cancer risk using Cox proportional hazards regression.Overall, preterm birth was not associated (HR 1.02, 95% CI 0.92, 1.14), and preeclampsia was inversely associated (HR 0.86, 95% CI 0.76, 0.99), with premenopausal breast cancer risk. In stratified analyses using data from 3 cohorts, preterm birth associations with breast cancer risk were modified by hypertensive conditions in first pregnancies (P-interaction = 0.09). Preterm birth was positively associated with premenopausal breast cancer in strata of women with preeclampsia or gestational hypertension (HR 1.52, 95% CI: 1.06, 2.18), but not among women with normotensive pregnancy (HR = 1.09, 95% CI: 0.93, 1.28). When stratified by preterm birth, the inverse association with preeclampsia was more apparent, but not statistically different (P-interaction = 0.2), among women who did not deliver preterm (HR = 0.82, 95% CI 0.68, 1.00) than those who did (HR = 1.07, 95% CI 0.73, 1.56).Findings support an overall inverse association of preeclampsia history with premenopausal breast cancer risk. Estimates for preterm birth and breast cancer may vary according to other conditions of pregnancy.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 肿瘤学
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第一作者机构: [1]Department of Epidemiology, Hazel B. Nichols, University of North Carolina at Chapel Hill Gillings School of Global Public Health, 2104F McGavran-Greenberg Hall, 135 Dauer Drive, Chapel Hill, Chapel Hill, NC 27599‑7435, USA
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