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Enhanced nuclear translation is associated with proliferation and progression across multiple cancers

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资源类型：
Pubmed体系：
作者：
Zou Sailan[1] * ; Kim Byung-Wook[2] * ; Tian Yan[1] * ; Liu Geng[1] ; Zhang Jiawei[2,3] ; Zerda Ricardo[4] ; Li Zhuo[4] ; Zhang Guixiang[5] ; Du Xiao[5,6] ; Lin Weiqiang[7] ; Gao Xiang[8] ; Huang Wendong[2,*1] ; Fu Xianghui[1,*2] ;
机构： [1]Division of Endocrinology and Metabolism State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu China. [2]Department of Diabetes Complications and Metabolism Arthur Riggs Diabetes and Metabolism Research Institute Irell & Manella Graduate School of Biological Sciences Beckman Research Institute City of Hope National Medical Center Duarte USA. [3]Cancer Institute (Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education) Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou China. [4]Electron Microscopy and Atomic Force Microscopy Core City of Hope National Medical Center Duarte USA. [5]Division of Gastrointestinal Surgery Department of General Surgery and Gastric Cancer Center West China Hospital Sichuan University Chengdu China. [6]Department of General Surgery Yaan People's Hospital Yaan China. [7]Department of Nephrology The Fourth Affiliated Hospital International Institutes of Medicine School of Medicine Zhejiang University Zhejiang China. [8]Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu China.
出处：
DOI： 10.1002/mco2.248

关键词： nucleolus proliferation proteomics ribosome translation tumorigenesis

摘要：
Recent technological advances have re-invigorated the interest in nuclear translation (NT), but the underlying mechanisms and functional implications of NT remain unknown. Here we show that NT is enhanced in malignant cancer cells and is associated with rapid cell growth. Nuclear ribopuromycylation analyses in a panel of diverse cell lines revealed that NT is scarce in normal immortalized cells, but is ubiquitous and robust in malignant cancer cells. Moreover, NT occurs in the nucleolus and requires normal nucleolar function. Intriguingly, NT is reduced by cellular stresses and anti-tumor agents and positively correlates with cancer cell proliferation and growth. By using a modified puromycin-associated nascent chain proteomics, we further identified numerous oncoproteins that are preferentially translated in the nucleus, such as transforming growth factor-beta 2 (TGFB2) and nucleophosmin 1 (NMP1). Specific overexpression of TGFB2 and NMP1 messenger RNAs in the nucleus can increase their protein levels and promote tumorigenesis. These findings establish a previously unknown link between NT and malignancy and suggest that cancer cells might have adapted a mechanism of NT to support their need for rapid growth, which highlight the potential of NT in tumorigenesis and might also open up new possibilities for therapeutic targeting of cancer-specific cellular functions.© 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

基金：
National Natural Science Foundation of China, Grant/Award Numbers: 82172986, 92157205, 81970561; Ministry of Science and Technology of China, Grant/Award Number: 2018ZX09201018-005; the National Cancer Institute, Grant/Award Number: 2R01CA139158; the John Hench Foundation; the 1.3.5 Project for Disciplines of Excellence,West China Hospital, Sichuan University, Grant/Award Number: ZYJC18049
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 医学：研究与实验
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 医学：研究与实验
第一作者：
第一作者机构： [1]Division of Endocrinology and Metabolism State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu China.
共同第一作者：
通讯作者：
通讯机构： [1]Division of Endocrinology and Metabolism State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu China. [2]Department of Diabetes Complications and Metabolism Arthur Riggs Diabetes and Metabolism Research Institute Irell & Manella Graduate School of Biological Sciences Beckman Research Institute City of Hope National Medical Center Duarte USA. [*1]Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA [*2]Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy and Cancer Center,West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, Sichuan, China
推荐引用方式(GB/T 7714)：
Zou Sailan,Kim Byung-Wook,Tian Yan,et al.Enhanced nuclear translation is associated with proliferation and progression across multiple cancers[J].MedComm.2023,4(3):e248.doi:10.1002/mco2.248.
APA：
Zou Sailan,Kim Byung-Wook,Tian Yan,Liu Geng,Zhang Jiawei...&Fu Xianghui.(2023).Enhanced nuclear translation is associated with proliferation and progression across multiple cancers.MedComm,4,(3)
MLA：
Zou Sailan,et al."Enhanced nuclear translation is associated with proliferation and progression across multiple cancers".MedComm 4..3(2023):e248

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