详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Radiation‑induced pure red cell aplasia combined with acquired amegakaryocytic thrombocytopenia in a thymoma after rapid response to radiotherapy: A case report and literature review

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Lung Cancer Center and Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

出处：

DOI：

ISSN：

关键词： pure red cell aplasia acquired amegakaryocytic thrombocytopenia thymoma radiotherapy surgery

摘要：

Thymoma combined with pure red cell aplasia (PRCA) and acquired amegakaryocytic thrombocytopenia (AAMT) has been rarely reported, often occurring in the initial stage of treatment and after chemotherapy or thymectomy, while PRCA and AAMT occurring after radiotherapy for thymoma has not been reported. The present study describes the case of a 42-year-old female patient with thymoma complicated by radiation-induced PRCA and AAMT after a rapid response to radiotherapy, who was in complete remission without recurrence after adjustment of initial symptomatic therapy to cyclosporine combined with prednisone. After 1 month, the patient underwent complete resection of mediastinal tumor. Next-generation sequencing revealed that the DNA damage repair pathway-related gene MSH3 was mutated, with p.A57P in abundance of 9.21%. To the best of our knowledge, the present study is the first to report that PRCA and AAMT secondary to thymoma after radiotherapy may be associated with increased sensitivity to radiotherapy caused by a mutation in the MSH3 gene.Copyright: © Xue et al.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2023]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

第一作者：

第一作者机构： [1]Lung Cancer Center and Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

共同第一作者：

通讯作者：

通讯机构： [1]Lung Cancer Center and Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China. [*1]Lung Cancer Center and Institute, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou, Chengdu, Sichuan 610041, P.R. China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Pretreatment biopsy for histological diagnosis and induction therapy in thymic tumors [2]基于中国胸腺瘤协作组回顾性数据库对比Masaoka-Koga分期和国际肺癌协会/国际胸腺肿瘤协作组提出的TNM分期系统 [3]良恶性胸腺瘤CT表现及诊断价值 [4]Comparable Survival between Additional Radiotherapy and Local Surgery in Occult Breast Cancer after Axillary Lymph Node Dissection: A Population-based Analysis [5]Short-course radiotherapy with immediate or delayed surgery in rectal cancer: A meta-analysis. [6]Superior Vena Cava Replacement Combined with Veno-Venous Shunt for Lung Cancer and Thymoma: Case Series [7]The effect of local treatment modalities in patients with early-stage adenocarcinoma of the uterine cervix: A population-based analysis [8]Identification of prognostic and subtype-specific potential miRNAs in thymoma [9]Primary mediastinal sarcoma: surgical outcomes of 21 cases [10]CT-guided percutaneous radiofrequency ablation in the treatment of stage I thymoma