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Integrated printed BDNF-stimulated HUCMSCs-derived exosomes/collagen/chitosan biological scaffolds with 3D printing technology promoted the remodelling of neural networks after traumatic brain injury

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机构： [1]Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, China. [2]National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610064, China. [3]Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury and Neuroscience, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin 300162, China. [4]Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610064, China. [5]Department of Liver Surgery & Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. [6]The 947th Hospital of Chinese People's Liberation Army, Xinjiang Uygur Autonomous Region, Kashgar 844000, China. [7]The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, China. [8]Intensive Care Unit, Traditional Chinese Medicine Hospital of Xinjiang Uyghur Autonomous Region and Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830000, China.

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关键词： collagen chitosan BDNF exosomes mesenchymal stem cell traumatic brain injury

摘要：

The restoration of nerve dysfunction after traumatic brain injury (TBI) faces huge challenges due to the limited self-regenerative abilities of nerve tissues. In situ inductive recovery can be achieved utilizing biological scaffolds combined with endogenous human umbilical cord mesenchymal stem cells (HUCMSCs)-derived exosomes (MExos). In this study, brain-derived neurotrophic factor-stimulated HUCMSCs-derived exosomes (BMExos) were composited with collagen/chitosan by 3D printing technology. 3D-printed collagen/chitosan/BMExos (3D-CC-BMExos) scaffolds have excellent mechanical properties and biocompatibility. Subsequently, in vivo experiments showed that 3D-CC-BMExos therapy could improve the recovery of neuromotor function and cognitive function in a TBI model in rats. Consistent with the behavioural recovery, the results of histomorphological tests showed that 3D-CC-BMExos therapy could facilitate the remodelling of neural networks, such as improving the regeneration of nerve fibres, synaptic connections and myelin sheaths, in lesions after TBI.© The Author(s) 2022. Published by Oxford University Press.

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出版当年[2023]版：

大类 | 1 区医学

小类 | 2 区材料科学：生物材料

最新[2023]版：

大类 | 1 区医学

小类 | 2 区材料科学：生物材料

第一作者：

第一作者机构： [1]Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, China. [2]National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610064, China.

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Integrated printed BDNF-stimulated HUCMSCs-derived exosomes/collagen/chitosan biological scaffolds with 3D printing technology promoted the remodelling of neural networks after traumatic brain injury

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