详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Voxel-S-value methods adapted to heterogeneous media for quantitative Y-90 microsphere radioembolization dosimetry

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Biomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau SAR, China [2]Center for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Taipa, Macau SAR, China [3]Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province. No. 25, Taiping St., Luzhou, Sichuan, China [4]Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR, China

出处：

DOI：

ISSN：

关键词： Yttrium-90 microsphere Tc-99m macroaggregated albumin Radioembolization Quantitative imaging Voxel-S-value

摘要：

The absorbed dose estimation from Voxel-S-Value (VSV) method in heterogeneous media is suboptimal as VSVs are calculated in homogeneous media. The aim of this study is to develop and evaluate new VSV methods in order to enhance the accuracy of Y-90 microspheres absorbed dose estimation in liver, lungs, tumors and lung-liver interface regions.Ten patients with Y-90 microspheres SPECT/CT and PET/CT data, six of whom had additional Tc-99m-macroaggregated albumin SPECT/CT data, were analyzed from the Deep Blue Data Repository. Seven existing VSV methods along with three newly proposed VSV methods were evaluated: liver and lung kernel with center voxel scaling (LiLuCK), liver kernel with density correction and lung kernel with center voxel scaling (LiKDLuCK), liver kernel with center voxel scaling and lung kernel with density correction (LiCKLuKD). Monte Carlo (MC) results were regarded as the gold standard. Absolute absorbed dose errors (%AADE) of these methods for the liver, lungs, tumors, upper liver, and lower lungs were assessed.Liver and tumor's median %AADE of all methods were <3% for three types of imaging data. In the lungs, however, three recently proposed VSV methods provided median %AADEs of less than 7%, whereas the differences exceeded 20% for existing methods that did not use a lung kernel. LiCKLuKD could achieve median %AADE <2% in the liver, upper liver and tumors, and median %AADE <7% in the lungs and lower lungs in three types of data.All methods are consistent with MC in the liver and tumors. Methods with tissue-specific kernel and effective correction achieve smaller errors in lungs. LiCKLuKD has comparable results with MC in absorbed dose estimation of Y-90 radioembolization for all target regions.Copyright © 2022 The Author(s). Published by Elsevier GmbH.. All rights reserved.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区核医学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区核医学

第一作者：

第一作者机构： [1]Biomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau SAR, China

通讯作者：

通讯机构： [1]Biomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau SAR, China [2]Center for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Taipa, Macau SAR, China [3]Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province. No. 25, Taiping St., Luzhou, Sichuan, China [4]Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR, China [*1]The Affiliated Hospital of Southwest Medical University, Taiping St., Luzhou, Sichuan, 646000, China. G.S.P. Mok, University of Macau, Macau SAR 999078, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Voxel-S-value methods adapted to heterogeneous media for quantitative Y-90 microsphere radioembolization dosimetry

文献详情

相关文献