机构：[1]School of Basic Medical Sciences, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.[2]State Key Laboratory of Biotherapy and Cancer Center, West China School of Basic Medical Sciences & Forensic Medicine, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.四川大学华西医院[3]Department of Encephalopathy, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China.[4]Hainan Cancer Center and Tumor Institute, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China.[5]Department of Otorhinolaryngology and Head and Neck Surgery, The Affiliated Lihuili Hospital, Ningbo University, Ningbo 315040, China.
Polyphenol, one of the major components that exert the therapeutic effect of Chinese herbal medicine (CHM), comprises several categories, including flavonoids, phenolic acids, lignans and stilbenes, and has long been studied in oncology due to its significant efficacy against cancers in vitro and in vivo. Recent evidence has linked this antitumor activity to the role of polyphenols in the modulation of redox homeostasis (e.g., pro/antioxidative effect) in cancer cells. Dysregulation of redox homeostasis could lead to the overproduction of reactive oxygen species (ROS), resulting in oxidative stress, which is essential for many aspects of tumors, such as tumorigenesis, progression, and drug resistance. Thus, investigating the ROS-mediated anticancer properties of polyphenols is beneficial for the discovery and development of novel pharmacologic agents. In this review, we summarized these extensively studied polyphenols and discussed the regulatory mechanisms related to the modulation of redox homeostasis that are involved in their antitumor property. In addition, we discussed novel technologies and strategies that could promote the development of CHM-derived polyphenols to improve their versatile anticancer properties, including the development of novel delivery systems, chemical modification, and combination with other agents.
基金：
Hainan Province Science and Technology
special fund (ZDYF2020132, ZDYF2020137, ZDYF2022SHFZ065), the specific research fund of the
Innovation Platform for Academicians of Hainan Province (YSPTZX202208), the Hainan Province
Clinical Medical Center (QWYH202175), Ningbo Clinical Research Center for Otolaryngology Head
and Neck Disease (No. 2022L005), and the Ningbo Medical and Health Brand Discipline (No.
PPXK2018-02).
第一作者机构：[1]School of Basic Medical Sciences, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Lei,Jin Ping,Guan Yueyue,et al.Exploiting Polyphenol-Mediated Redox Reorientation in Cancer Therapy[J].PHARMACEUTICALS.2022,15(12):doi:10.3390/ph15121540.
APA：
Li Lei,Jin Ping,Guan Yueyue,Luo Maochao,Wang Yu...&Shen Zhisen.(2022).Exploiting Polyphenol-Mediated Redox Reorientation in Cancer Therapy.PHARMACEUTICALS,15,(12)
MLA：
Li Lei,et al."Exploiting Polyphenol-Mediated Redox Reorientation in Cancer Therapy".PHARMACEUTICALS 15..12(2022)
