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Targeting hypoxia-inducible factors for breast cancer therapy: A narrative review

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机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China. [2]Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China. [3]South Sichuan Institute of Translational Medicine, Luzhou, China. [4]Department of Pharmacy, The Second People's Hospital of Jiangyou, Mianyang, China. [5]Department of Pharmacy, The People's Hospital of Wusheng, Guang'an, China. [6]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

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关键词： hypoxia-inducible factors breast cancer drug delivery systems tumor microenvironment angiogenesis glycolysis

摘要：

Hypoxia-inducible factors (HIFs), central regulators for cells to adapt to low cellular oxygen levels, are often overexpressed and activated in breast cancer. HIFs modulate the primary transcriptional response of downstream pathways and target genes in response to hypoxia, including glycolysis, angiogenesis and metastasis. They can promote the development of breast cancer and are associated with poor prognosis of breast cancer patients by regulating cancer processes closely related to tumor invasion, metastasis and drug resistance. Thus, specific targeting of HIFs may improve the efficiency of cancer therapy. In this review, we summarize the advances in HIF-related molecular mechanisms and clinical and preclinical studies of drugs targeting HIFs in breast cancer. Given the rapid progression in this field and nanotechnology, drug delivery systems (DDSs) for HIF targeting are increasingly being developed. Therefore, we highlight the HIF related DDS, including liposomes, polymers, metal-based or carbon-based nanoparticles.Copyright © 2022 Luo, Jiang, Anfu Zheng, Zhao, Wu, Li, Du, Chen, Deng, Chen, Li, Li, Gu, Sun, Xiao and Shen.

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出版当年[2022]版：

大类 | 2 区

医学

小类 | 2 区药学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区药学

第一作者：

第一作者机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China. [2]Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China. [3]South Sichuan Institute of Translational Medicine, Luzhou, China. [4]Department of Pharmacy, The Second People's Hospital of Jiangyou, Mianyang, China.

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通讯作者：

通讯机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China. [2]Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China. [3]South Sichuan Institute of Translational Medicine, Luzhou, China. [6]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

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