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Advances in the design and application of glycolysis-related nanodelivery systems for anti-tumor

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机构： [1]Hunan Provincial Key Laboratory of Basic and Clinical Pharmacological Research of Gastrointestinal Cancer, Department of Pharmacy, Institute of Pharmacy and Pharmacology, the Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China [2]Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. [3]School of Nursing, Hengyang Medicial School, University of South China, Hengyang, Hunan 421001, China. [4]The First Affiliated Hospital, Department of Pharmacy, University of South China, Hengyang, Hunan 421001, China. [5]Innovation Centre for Science and Technology, North Sichuan Medical College, Nanchong, Sichuan 637000, China. [6]The College of Pharmacy, Xiangnan University, Chenzhou, Hunan 423000, China. [7]Hengyang Xiaoju Pharmaceutical Co., Ltd, Hengyang, Hunan 421001, China.

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关键词： Glycolysis pathway Drug delivery systems Anti-tumor nanodelivery systems

摘要：

Hypoxia is a common feature of solid tumors, and activation of hypoxia-inducing factors in the tumor hypoxia microenvironment can lead to complex reprogramming of glucose metabolism in tumor cells. In particular, the unique glucose metabolism pattern of tumor cells, mainly glycolysis pathway, provides conditions for tumor growth, metastasis, immune escape and drug resistance. Drug development for glycolysis-related targets is more targeted and safer than traditional chemotherapy drugs, and drug delivery systems offer favorable strategies for improving the targeted therapy of these drugs in vivo. Here, we review drug delivery systems that target tumor glycolysis, including specific small molecule inhibitors, siRNA, and other nanodelivery systems that affect glycolysis, and note the multifunctional anti-tumor nanodelivery systems that combine multiple therapeutic modalities including chemotherapy, photothermal, photodynamic, sonodynamic, chemodynamic therapies, as well as photoacoustic, magnetic resonance imaging. Several major challenges and future directions in the development and transformation of anti-tumor nanostrategies for glycolysis are discussed. The development of innovative anti-tumor nanodelivery systems related to tumor glycolysis could provide powerful weapons against tumor progression in the foreseeable future.Copyright © 2025 Elsevier B.V. All rights reserved.

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出版当年[2025]版：

大类 | 2 区医学

小类 | 1 区生物物理 3 区材料科学：生物材料

最新[2025]版：

大类 | 2 区医学

小类 | 1 区生物物理 3 区材料科学：生物材料

第一作者：

第一作者机构： [1]Hunan Provincial Key Laboratory of Basic and Clinical Pharmacological Research of Gastrointestinal Cancer, Department of Pharmacy, Institute of Pharmacy and Pharmacology, the Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China [2]Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.

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通讯机构： [1]Hunan Provincial Key Laboratory of Basic and Clinical Pharmacological Research of Gastrointestinal Cancer, Department of Pharmacy, Institute of Pharmacy and Pharmacology, the Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China [2]Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. [7]Hengyang Xiaoju Pharmaceutical Co., Ltd, Hengyang, Hunan 421001, China.

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Advances in the design and application of glycolysis-related nanodelivery systems for anti-tumor

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