机构：[1]Department of Oncology and Hematology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, China.[2]Center of Excellence for Molecular Imaging (CEMI), Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.[3]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China.[4]Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Southwest Medical University, Luzhou 646000, China.[5]South Sichuan Institute of Translational Medicine, Luzhou 646000, China.[6]Department of Pharmacy, People's Hospital of Nanbu County, Nanchong 637300, China.[7]Center of Radiation Research and Medical Imaging, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Lung cancer is the second leading cause of cancer-related death worldwide. In recent decades, investigators have found that microRNAs, a group of non-coding RNAs, are abnormally expressed in lung cancer, and play important roles in the initiation and progression of lung cancer. These microRNAs have been used as biomarkers and potential therapeutic targets of lung cancer. Polyphenols are natural and bioactive chemicals that are synthesized by plants, and have promising anticancer effects against several kinds of cancer, including lung cancer. Recent studies identified that polyphenols exert their anticancer effects by regulating the expression levels of microRNAs in lung cancer. Targeting microRNAs using polyphenols may provide a novel strategy for the prevention and treatment of lung cancer. In this review, we reviewed the effects of polyphenols on oncogenic and tumor-suppressive microRNAs in lung cancer. We also reviewed and discussed the potential clinical application of polyphenol-regulated microRNAs in lung cancer treatment.
基金：
Chiang Mai University, by the Science and Technology
Research Fund of Sichuan Administration of Traditional Chinese Medicine (No. 2021MS528),
and by the Science and Technology Strategic Cooperation Programs of Luzhou Municipal People’s
Government and Southwest Medical University (Grant nos. 2019LZXNYDJ45).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区化学
小类|3 区化学：综合3 区生化与分子生物学
最新[2023]版：
大类|2 区化学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[1]Department of Oncology and Hematology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, China.[2]Center of Excellence for Molecular Imaging (CEMI), Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
共同第一作者：
通讯作者：
通讯机构：[2]Center of Excellence for Molecular Imaging (CEMI), Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.[3]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China.[4]Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Southwest Medical University, Luzhou 646000, China.[5]South Sichuan Institute of Translational Medicine, Luzhou 646000, China.[7]Center of Radiation Research and Medical Imaging, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
推荐引用方式(GB/T 7714)：
Li Jing,Zhong Xianmei,Zhao Yueshui,et al.Polyphenols as Lung Cancer Chemopreventive Agents by Targeting microRNAs[J].Molecules (Basel, Switzerland).2022,27(18):doi:10.3390/molecules27185903.
APA：
Li Jing,Zhong Xianmei,Zhao Yueshui,Shen Jing,Pilapong Chalermchai&Xiao Zhangang.(2022).Polyphenols as Lung Cancer Chemopreventive Agents by Targeting microRNAs.Molecules (Basel, Switzerland),27,(18)
MLA：
Li Jing,et al."Polyphenols as Lung Cancer Chemopreventive Agents by Targeting microRNAs".Molecules (Basel, Switzerland) 27..18(2022)
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