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Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis

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资源类型：
Pubmed体系：
作者：
Zhu Yihan[1,2] ; Yang Ying[1] ; Bu Hong[3] ; Huang Hong[1,2] ; Chen Hongyu[1,2] ; Ran Jingjing[4] ; Qin Liwen[5] ; Ni Yinyun[1] ; Yao Menglin[1] ; Song Tingting[1] ; Li Mufeng[6] ; Yang Yongfeng[1] ; Guo Tingting[1] ; Chao Ningning[1] ; Liu Zhiqing[1] ; Li Weimin[1,*1] ; Zhang Li[1,*2] ;
机构： [1]Department of Respiratory and Critical Care Medicine, Institute of Respiratory Health, Precision Medicine Key Laboratory of Sichuan Province, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China. [2]Institute of Clinical Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China. [3]Department of Pathology, West China Hospital, Sichuan University, Chengdu, China. [4]Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China. [5]Administration of Research Park, West China Hospital, Sichuan University, Chengdu, China. [6]Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.
出处：
DOI： 10.1111/cas.15515
ISSN：

关键词： apelin glutamine deamidation HMGA1 lipid metabolism lung tumorigenesis

摘要：
Enhanced fatty acid synthesis provides proliferation and survival advantages for tumor cells. Apelin is an adipokine, which serves as a ligand of G protein-coupled receptors that promote tumor growth in malignant cancers. Here, we confirmed that apelin increased sterol regulatory element-binding protein 1 (SREBP1) activity and induced the expression of glutamine amidotransferase for deamidating high-mobility group A 1 (HMGA1) to promote fatty acid synthesis and proliferation of lung cancer cells. This post-translational modification stabilized the HMGA1 expression and enhanced the formation of the apelin-HMGA1-SREBP1 complex to facilitate SREBP1 activity for lipid metabolism and lung cancer cell growth. We uncovered the pivotal role of apelin-mediated deamidation of HMGA1 in lipid metabolism and tumorigenesis of lung cancer cells.© 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

基金：
National Natural Science Foundation of China, Grant/Award Number: 81772478, 81974363 and 821733251; the Clinical Research Incubation Project of West China Hospital of Sichuan University, Grant/Award Number: 2018HXFH102; the Hospital Enterprise Cooperative Clinical Research Innovation Project, Grant/Award Number: 2019HXCX04; the Sichuan International/Hong Kong, Macao and Taiwan Science and technology innovation cooperation project, Grant/ Award Number: 2018hh0161
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学
第一作者：
第一作者机构： [1]Department of Respiratory and Critical Care Medicine, Institute of Respiratory Health, Precision Medicine Key Laboratory of Sichuan Province, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China. [2]Institute of Clinical Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China.
通讯作者：
通讯机构： [1]Department of Respiratory and Critical Care Medicine, Institute of Respiratory Health, Precision Medicine Key Laboratory of Sichuan Province, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China. [*1]Department of Respiratory and Critical Care Medicine, 37 Guoxue Alley, Wuhou district, West China Hospital of Sichuan University, Chengdu 610041, China. [*2]Institute of Respiratory Health, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, 88 Keyuan South Road, Wuhou District, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Zhu Yihan,Yang Ying,Bu Hong,et al.Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis[J].Cancer science.2022,doi:10.1111/cas.15515.
APA：
Zhu Yihan,Yang Ying,Bu Hong,Huang Hong,Chen Hongyu...&Zhang Li.(2022).Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis.Cancer science,,
MLA：
Zhu Yihan,et al."Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis".Cancer science .(2022)

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