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Genetic predispositions to psychiatric disorders and the risk of COVID-19

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资源类型：
Pubmed体系：
作者：
Chen Wenwen[1,2,3] * ; Zeng Yu[1,2] * ; Suo Chen[4] ; Yang Huazhen[1,2] ; Chen Yilong[1,2] ; Hou Can[1,2] ; Hu Yao[1,2] ; Ying Zhiye[1,2] ; Sun Yajing[1,2] ; Qu Yuanyuan[1,2] ; Lu Donghao[1,2,5,6] ; Fang Fang[5] ; Valdimarsdóttir Unnur A[5,6,7,8] ; Song Huan[1,2,7] ;
机构： [1]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China. [2]Med‑X Center for Informatics, Sichuan University, Chengdu, China. [3]Division of Nephrology, Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China. [4]Department of Epidemiology & Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai, China. [5]Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden. [6]Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, USA. [7]Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland. [8]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
出处：
DOI： 10.1186/s12916-022-02520-z

关键词： Genetic predisposition Psychiatric disorders COVID-19

摘要：
Whether a genetic predisposition to psychiatric disorders is associated with coronavirus disease 2019 (COVID-19) is unknown.Our analytic sample consisted of 287,123 white British participants in UK Biobank who were alive on 31 January 2020. We performed a genome-wide association study (GWAS) analysis for each psychiatric disorder (substance misuse, depression, anxiety, psychotic disorder, and stress-related disorders) in a randomly selected half of the study population ("base dataset"). For the other half ("target dataset"), the polygenic risk score (PRS) was calculated as a proxy of individuals' genetic predisposition to a given psychiatric phenotype using discovered genetic variants from the base dataset. Ascertainment of COVID-19 was based on the Public Health England dataset, inpatient hospital data, or death registers in UK Biobank. COVID-19 cases from hospitalization records or death records were considered "severe cases." The association between the PRS for psychiatric disorders and COVID-19 risk was examined using logistic regression. We also repeated PRS analyses based on publicly available GWAS summary statistics.A total of 143,562 participants (including 10,868 COVID-19 cases) were used for PRS analyses. A higher genetic predisposition to psychiatric disorders was associated with an increased risk of any COVID-19 and severe COVID-19. The adjusted odds ratio (OR) for any COVID-19 was 1.07 (95% confidence interval [CI] 1.02-1.13) and 1.06 (95% CI 1.01-1.11) among individuals with a high genetic risk (above the upper tertile of the PRS) for substance misuse and depression, respectively, compared with individuals with a low genetic risk (below the lower tertile). Slightly higher ORs were noted for severe COVID-19, and similar result patterns were obtained in analyses based on publicly available GWAS summary statistics.Our findings suggest a potential role of genetic factors in the observed phenotypic association between psychiatric disorders and COVID-19. Our data underscore the need for increased medical surveillance for this vulnerable population during the COVID-19 pandemic.© 2022. The Author(s).

基金：
This work is supported by the National Science Foundation of China (No. 81971262 to HS), West China Hospital COVID-19 Epidemic Science and Technology Project (No. HX-2019-nCoV-014 to HS), and Sichuan University Emergency Grant (No. 2020scunCoVyingji10002 to HS), Horizon2020 (CoMorMent, No. 847776 to FF and UAV), and NordForsk grant (COMORMENT, No.105668 to UV and FF).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 医学：内科
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 医学：内科
第一作者：
第一作者机构： [1]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China. [2]Med‑X Center for Informatics, Sichuan University, Chengdu, China. [3]Division of Nephrology, Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
共同第一作者：
通讯作者：
通讯机构： [1]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China. [2]Med‑X Center for Informatics, Sichuan University, Chengdu, China. [7]Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
推荐引用方式(GB/T 7714)：
Chen Wenwen,Zeng Yu,Suo Chen,et al.Genetic predispositions to psychiatric disorders and the risk of COVID-19[J].BMC medicine.2022,20(1):314.doi:10.1186/s12916-022-02520-z.
APA：
Chen Wenwen,Zeng Yu,Suo Chen,Yang Huazhen,Chen Yilong...&Song Huan.(2022).Genetic predispositions to psychiatric disorders and the risk of COVID-19.BMC medicine,20,(1)
MLA：
Chen Wenwen,et al."Genetic predispositions to psychiatric disorders and the risk of COVID-19".BMC medicine 20..1(2022):314

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