机构：[1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital Affiliate to School of Medicine, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院四川省肿瘤医院[2]MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China[3]Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu 2019RU035, China[4]Sichuan Institute for Brain Science and Brain-Inspired Intelligence, Chengdu 611731, China
Non-small cell lung cancer (NSCLC) accounts for more than 85% of all lung cancer cases, and chemotherapy-related brain changes (known as "chemobrain") in NSCLC patients were found in previous studies. However, the effects of platinum-based chemotherapy on brain structural networks are still unclear. Structural magnetic resonance imaging (sMRI) data were collected from 32 NSCLC patients following platinum-based chemotherapy, 36 NSCLC patients without chemotherapy, and 39 healthy controls. Clinical physiological indicators of patients were collected. Then, morphological similarity networks were constructed using MRI data, and topological properties were calculated using graph theory method. Differences between three groups were investigated using one-way ANOVA and two-sample t-test, and relations between topological properties and clinical physiological indicators were calculated. We found that degree and nodal efficiency in temporal-parietal networks were significantly reduced in NSCLC patients following platinum-based chemotherapy compared to healthy controls/patients without chemotherapy (F-test, p < 0.001; post hoc t-test, p < 0.01, Bonferroni corrected). These changes (p < 0.05) were positively correlated with clinical measures, including thrombocytes, granulocytes and hemoglobin, and were negatively correlated with measures of triglycerides and cholesterol levels. Network properties including clustering coefficient (F(2,104) = 41.435, p < 0.001), number of K-edges (F(2,104) = 40.304, p < 0.001), density of K-edges (F(2,104) = 40.304, p < 0.001), global efficiency (F(2,104) = 42.585, p < 0.001) and small-world (F(2,104) = 37.132, p < 0.001) were also significantly reduced (post hoc t-test, p < 0.01, Bonferroni corrected). These results indicate that platinum-based chemotherapy might cause cerebrovascular damage and clinical indicators' changes, which then cause the properties of morphological similarity networks' changes in the temporal and parietal lobes. This study may help us better understand the "chemobrain" in NSCLC patients.
基金：
The present study was financially supported by the Ministry
of Science and Technology of the People’s Republic China (No.
2017YFC0113904), the National Natural Science Foundation of China
(No. 61527815, 81861128001), the CAMS Innovation Fund for Medical
Sciences (2019-I2M-5–039), the Sichuan Science and Technology
Program (2018JZ0073, 2017SZ0004, 2021YJ0167) and the Science
and Technology Bereau of Chengdu (No. 2021YF0501659SN).
第一作者机构：[1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital Affiliate to School of Medicine, University of Electronic Science and Technology of China, Chengdu, China[2]MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
通讯作者：
通讯机构：[1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital Affiliate to School of Medicine, University of Electronic Science and Technology of China, Chengdu, China[2]MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China[3]Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu 2019RU035, China[4]Sichuan Institute for Brain Science and Brain-Inspired Intelligence, Chengdu 611731, China
推荐引用方式(GB/T 7714)：
Chen Gong,Wu Chuan,Liu Yuan,et al.Altered temporal-parietal morphological similarity networks in non-small cell lung cancer patients following chemotherapy: an MRI preliminary study[J].BRAIN IMAGING AND BEHAVIOR.2022,16(6):2543-2555.doi:10.1007/s11682-022-00709-7.
APA：
Chen, Gong,Wu, Chuan,Liu, Yuan,Fang, Zengyi,Luo, Liping...&Dong, Li.(2022).Altered temporal-parietal morphological similarity networks in non-small cell lung cancer patients following chemotherapy: an MRI preliminary study.BRAIN IMAGING AND BEHAVIOR,16,(6)
MLA：
Chen, Gong,et al."Altered temporal-parietal morphological similarity networks in non-small cell lung cancer patients following chemotherapy: an MRI preliminary study".BRAIN IMAGING AND BEHAVIOR 16..6(2022):2543-2555
