机构：[1]Department of Pharmacy, Sichuan Cancer Hospital & Institution, SichuanCancer Center, School of Medicine, University of Electronic Science and Technologyof China, Chengdu, China临床药学部临床药学部四川省人民医院四川省肿瘤医院[2]Targeted Tracer Research and DevelopmentLaboratory, Institute of Respiratory Health, Frontiers Science Centerfor Disease‑related Molecular Network, West China Hospital, Sichuan University,Chengdu, China四川大学华西医院[3]Laboratory Medicine Center, Sichuan Provincial Maternityand Child Health Care Hospital, Affiliated Women’s and Children’s Hospitalof Chengdu Medical College, Chengdu Medical College, Chengdu, China
The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of therapeutic resistance may provide new strategies for overcoming cancer resistance. N6-methyladenosine (m6A) is the most prevalent RNA modification in eukaryotes, and is involved in the regulation of RNA splicing, translation, transport, degradation, stability and processing, thus affecting several physiological processes and cancer progression. As a novel type of multifunctional non-coding RNAs (ncRNAs), circular RNAs (circRNAs) have been demonstrated to play vital roles in anticancer therapy. Currently, accumulating studies have revealed the mutual regulation of m6A modification and circRNAs, and their interaction can further influence the sensitivity of cancer treatment. In this review, we mainly summarized the recent advances of m6A modification and circRNAs in the modulation of cancer therapeutic resistance, as well as their interplay and potential mechanisms, providing promising insights and future directions in reversal of therapeutic resistance in cancer.
基金：
National Natural Science Foundation of China [81803931, 81703922]; Sichuan Science and Technology Program [2021YFH0144]
第一作者机构：[1]Department of Pharmacy, Sichuan Cancer Hospital & Institution, SichuanCancer Center, School of Medicine, University of Electronic Science and Technologyof China, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pharmacy, Sichuan Cancer Hospital & Institution, SichuanCancer Center, School of Medicine, University of Electronic Science and Technologyof China, Chengdu, China
推荐引用方式(GB/T 7714)：
Lin Hong,Wang Yuxi,Wang Pinghan,et al.Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance[J].MOLECULAR CANCER.2022,21(1):doi:10.1186/s12943-022-01620-x.
APA：
Lin, Hong,Wang, Yuxi,Wang, Pinghan,Long, Fangyi&Wang, Ting.(2022).Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance.MOLECULAR CANCER,21,(1)
MLA：
Lin, Hong,et al."Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance".MOLECULAR CANCER 21..1(2022)
医学