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Regulatory mechanisms of m6A RNA methylation in esophageal cancer: a comprehensive review

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机构: [1]Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China. [2]Graduate School, North Sichuan Medical College, Institute of Surgery, Nanchong, China. [3]Graduate School, Institute of Surgery, Chengdu University of Traditional Chinese Medicine, Chengdu, China. [4]Department of Physical Examination, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China. [5]Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
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关键词: esophageal cancer RNA modification N6-methyladenosine occurrence treatment

摘要:
Esophageal cancer is an aggressively malignant neoplasm characterized by a high mortality rate. Frequently diagnosed at an advanced stage, it presents challenges for optimal therapeutic intervention due to its non-specific symptoms, resulting in lost opportunities for effective treatment, such as surgery, radiotherapy, chemotherapy and target therapy. The N6-methyladenosine (m6A) modification represents the most critical post-transcriptional modification of eukaryotic messenger RNA (mRNA). The reversible m6A modification is mediated by three regulatory factors: m6A methyltransferases, demethylating enzymes, and m6A recognition proteins. These components identify and bind to specific RNA methylation sites, thereby modulating essential biological functions such as RNA processing, nuclear export, stability, translation and degradation, which significantly influence tumorigenesis, invasion, and metastasis. Given the importance of m6A modification, this paper offers a comprehensive examination of the regulatory mechanisms, biological functions, and future therapeutic implications of m6A RNA methylation in the context of esophageal cancer.Copyright © 2025 Wen, Fu, Wang, Xie, Tang, Yu and Zhou.

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大类 | 3 区 生物学
小类 | 3 区 遗传学
最新[2025]版:
大类 | 3 区 生物学
小类 | 3 区 遗传学
第一作者:
第一作者机构: [1]Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China. [2]Graduate School, North Sichuan Medical College, Institute of Surgery, Nanchong, China.
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通讯作者:
通讯机构: [1]Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China. [2]Graduate School, North Sichuan Medical College, Institute of Surgery, Nanchong, China. [3]Graduate School, Institute of Surgery, Chengdu University of Traditional Chinese Medicine, Chengdu, China. [5]Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
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