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Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Han Luo[1,2,3,4] ; Xuyang Xia[4,5] ; Li-Bin Huang[3,6] ; Hyunsu An [7] ; Minyuan Cao[5] ; Gyeong Dae Kim[7] ; Hai-Ning Chen[3,8] ; Wei-Han Zhang[3,9] ; Yang Shu[5,9] ; Xiangyu Kong[1,2,3] ; Zhixiang Ren[5] ; Pei-Heng Li[1,2,3] ; Yang Liu[1,2,3] ; Huairong Tang[10] ; Ronghao Sun[1,2,11] ; Chao Li[11] ; Bing Bai[12] ; Weiguo Jia[13] ; Yi Liu[14] ; Wei Zhang[15] ; Li Yang[5] ; Yong Peng[5] ; Lunzhi Dai[5] ; Hongbo Hu[5] ; Yong Jiang[16] ; Yiguo Hu[1,5] ; Jingqiang Zhu[1,2] ; Hong Jiang[5] ; Zhihui Li[1,2] ; Carlos Caulin[17] ; Jihwan Park[7] ; Heng Xu[4,5] ;
机构： [1]Division of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China [2]Laboratory of thyroid and parathyroiddisease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China [3]Department ofGeneral Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China [4]Division of Laboratory Medicine/Research Centre of Clinical LaboratoryMedicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China [5]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital,Sichuan University, Chengdu, Sichuan, China [6]Division of Gastrointestinal Surgery, State Key Laboratory of Biotherapy, West China Hospital, SichuanUniversity, Chengdu, Sichuan, China [7]School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea [8]ColorectalCancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China [9]Gastric Cancer Center, West China Hospital, Sichuan University,Chengdu, Sichuan, China [10]Health Promotion Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China [11]Department of Head and NeckSurgery, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China,Chengdu, Sichuan, China [12]State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Scienceand Technology.Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China [13]Center for Geriatrics medicine, West China Hospital,Sichuan University, Chengdu, Sichuan, China [14]Division of Rheumatism & Immunology, Rare Diseases Center, West Chia Hospital, Sichuan University,Chengdu, Sichuan, China [15]Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University,Changsha, Hunan, China [16]Division of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, China [17]Department of Otolaryngology - Head& Neck Surgery and University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
出处：
DOI： 10.1038/s41467-022-34395-2
ISSN：

摘要：
Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor microenvironment (TME) and influence cancer hallmarks, but without systematic investigation on their ubiquitous characteristics across different cancer types. Here, we perform pan-cancer analysis on 226 samples across 10 solid cancer types to profile the TME at single-cell resolution, illustrating the commonalities/plasticity of heterogenous CAFs. Activation trajectory of the major CAF types is divided into three states, exhibiting distinct interactions with other cell components, and relating to prognosis of immunotherapy. Moreover, minor CAF components represent the alternative origin from other TME components (e.g., endothelia and macrophages). Particularly, the ubiquitous presentation of endothelial-to-mesenchymal transition CAF, which may interact with proximal SPP1+ tumor-associated macrophages, is implicated in endothelial-to-mesenchymal transition and survival stratifications. Our study comprehensively profiles the shared characteristics and dynamics of CAFs, and highlight their heterogeneity and plasticity across different cancer types. Browser of integrated pan-cancer single-cell information is available at https://gist-fgl.github.io/sc-caf-atlas/ .© 2022. The Author(s).

基金：
National Key R&D Program of China (No. 2021YFA1301203(H.X.), 2018YFC2000305(L.Z.D.)), National Natural Science Foundation of China (82103031(H.L.), 81973408(H.X.), 82272933 (H.L.), 82273445(Y.S.)), International Cooperation Project of Chengdu Municipal Science and Technology Bureau (2020-GH02-00017-HZ(H.L.)), 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (No. ZYYC20003(H.X.), ZYJC18035(H.L.), ZYJC18025(Z.H.L.), ZYJC18003(Y.L.), ZYJC18004(H.X.), and ZYYC20007(L.D.)), and the National Research Foundation of Korea funded by the Korean government (2019R1C1C1005403(J.P), 2019R1A4A1028802(J.P), 2021M3H9A2097520(J.P)), Clinical Research Incubation Project, West China Hospital, Sichuan University (22HXFH019(H.L)).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2023]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
JCR分区：
出版当年[2022]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Division of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China [2]Laboratory of thyroid and parathyroiddisease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China [3]Department ofGeneral Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China [4]Division of Laboratory Medicine/Research Centre of Clinical LaboratoryMedicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China
共同第一作者：
通讯作者：
通讯机构： [1]Division of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China [2]Laboratory of thyroid and parathyroiddisease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China [3]Department ofGeneral Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China [4]Division of Laboratory Medicine/Research Centre of Clinical LaboratoryMedicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China [5]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital,Sichuan University, Chengdu, Sichuan, China
推荐引用方式(GB/T 7714)：
Han Luo,Xuyang Xia,Li-Bin Huang,et al.Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment[J].NATURE COMMUNICATIONS.2022,13(1):doi:10.1038/s41467-022-34395-2.
APA：
Han Luo,Xuyang Xia,Li-Bin Huang,Hyunsu An,Minyuan Cao...&Heng Xu.(2022).Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment.NATURE COMMUNICATIONS,13,(1)
MLA：
Han Luo,et al."Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment".NATURE COMMUNICATIONS 13..1(2022)

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