机构:[1]1 Gynecologic Oncology Center, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China,
Objective: We aimed to evaluate the clinicopathological characteristics and
survival outcomes of patients with second primary ovarian carcinomas after a
breast cancer diagnosis.
Materials and methods: We reviewed the medical reports of 23 patients at
Sichuan Cancer Hospital between May 2002 and October 2021. We analyzed
demographic and clinicopathologic characteristics, the time interval between
diagnoses, and survival time. Kaplan-Meier and Cox proportional hazards
regression tests were used to determine survival outcomes.
Results: The median age of patients at the time of diagnosis of breast cancer (BC) and
ovarian cancer (OC) was 46 and 49 years, respectively. Among them were 6 cases of
synchronous OC and 17 instances of metachronous OC. The average interval
between diagnoses of the two cancers was 62.48 months. The median OS after
the second primary OC diagnosis was 38 months. According to Kaplan-Meier’s
analysis, the advanced stage at presentation of BC (p=0.023) resulted in a significantly
shorter interval between BC and OC diagnosis. On univariate Cox regression analysis,
only BC Scarff-Bloom-Richardson (SBR) 3 Grade resulted in a considerably worse PFS
(HR 0.187, p=0.048) and OS (HR 0.190, p=0.048), respectively.
Conclusion: We should strengthen the follow-up management of breast cancer
patients.The later the stage of breast cancer, the shorter the time interval of
diagnosis of OC was. Early control of ovarian tumors and active comprehensive
treatment for synchronous and metachronous breast and ovarian cancer can
achieve good results.
语种:
外文
中科院(CAS)分区:
出版当年[2025]版:
大类|3 区医学
小类|4 区肿瘤学
最新[2025]版:
大类|3 区医学
小类|4 区肿瘤学
第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Hong Liu,Guonan Zhang.second primary ovarian carcinomas after breast cancer diagnosis- an analysis of a single cancer centre in China[J].Frontiers in Oncology.2025,doi:10.3389/fonc.2025.1553366.
APA:
Hong Liu&Guonan Zhang.(2025).second primary ovarian carcinomas after breast cancer diagnosis- an analysis of a single cancer centre in China.Frontiers in Oncology,,
MLA:
Hong Liu,et al."second primary ovarian carcinomas after breast cancer diagnosis- an analysis of a single cancer centre in China".Frontiers in Oncology .(2025)