A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer (PALOMA-2)
研究单位：[1]Janssen Research & Development,LLC[2]s Hospital Liuzhou,China,545006[3]University of California,Irvine Orange,California,United States,92868[4]Stanford University Palo Alto,California,United States,94304[5]H. Lee Moffitt Cancer & Research Institute Tampa,Florida,United States,33612[6]Northwestern University Chicago,Illinois,United States,60611[7]University of Kansas Cancer Center Westwood,Kansas,United States,66205[8]Johns Hopkins University Baltimore,Maryland,United States,21287[9]Rutgers Cancer Institute of New Jersey New Brunswick,New Jersey,United States,08901[10]Montefiore Medical Center Bronx,New York,United States,10461[11]Hemotology Oncology Associates of CNY East Syracuse,New York,United States,13057[12]Cleveland Clinic Cleveland,Ohio,United States,44195[13]The Huntsman Cancer Institute Salt Lake City,Utah,United States,84112[14]Virginia Cancer Specialists Fairfax,Virginia,United States,22031[15]Swedish Cancer Institute Seattle,Washington,United States,98104[16]Fundacao Pio XII Barretos,Brazil,14784-400[17]PERSONAL - Oncologia de Precisão e Personalizada Belo Horizonte,Brazil,30130 090[18]Hospital do Cancer de Londrina Londrina,Brazil,86015[19]Associação Hospitalar Moinhos de Vento Porto Alegre,Brazil,90035-001[20]Instituto D'Or de Pesquisa e Ensino (IDOR) Rio de Janeiro,Brazil,22281-100[21]Instituto D'Or de Pesquisa e Ensino (IDOR) Salvador,Brazil,41253-190[22]Fundação Antônio Prudente - A.C. Camargo Cancer Center Sao Paulo,Brazil,01509900[23]Hospital Alemão Oswaldo Cruz São Paulo,Brazil,01327-001[24]Hospital Nove de Julho São Paulo,Brazil,01409-001[25]Beijing Cancer Hospital of Peking University Beijing,China,100142[26]Jilin cancer hospital Changchun,China,130000[27]Sichuan Cancer Hospital Chengdu,China,610041[28]West China Hospital,Sichuan University Chengdu,China,610047[29]Southwest Hospital ChongQing,China,400038[30]The First Affiliated Hospital,Sun Yat-sen University Guangzhou,China,510060[31]The First Affiliated Hospital,Zhejiang University College of Medicine Hangzhou,China,310003[32]Sir Run Run Shaw Hospital,Zhejiang University School of Medicine Hangzhou,China,310016[33]Harbin medical university cancer hospital Harbin,China,150081[34]Huizhou Municipal Central Hospital Huizhou,China,516001[35]Liuzhou people'[36]Fudan University Shanghai Cancer Center Shanghai,China,200032[37]Tianjin Medical University General Hospital Tianjin,China,300052[38]The First Affiliated Hospital of Wenzhou Medical University Wenzhou,China,325000[39]Union Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan,China,430022[40]Hospital of Jiangnan University Wuxi,China,214122[41]The First Affiliated Hospital of Xi'an Jiaotong University Xi'an,China,710061[42]Yantai Yuhuangding Hospital Yantai,China,264000[43]Centre Francois Baclesse Caen Cedex 05,France,14076[44]Centre Georges-François Leclerc Dijon,France,21079[45]Centre Leon Bérard Lyon Cedex 8,France,69373[46]Institut Curie PARIS Cedex 5,France,75248[47]Institut de cancerologie de l'ouest Saint-Herblain Cedex,France,44805[48]Gustave Roussy Villejuif Cedex,France,94800[49]Evangelische Lungenklinik Berlin Berlin,Germany,13125[50]LungenClinic Grosshansdorf GmbH Grosshandorf,Germany,22927[51]Lungenfachklinik Immenhausen Immenhausen,Germany,34376[52]Universitaetsklinikum Koeln Koeln,Germany,50937[53]Klinikum Würzburg Mitte gGmbH Standort Missioklinik Wuerzburg,Germany,97074[54]Rambam Medical Center Department of Pediatric Pulmonology Meyer Childern's Hospital Haifa,Israel,3109601[55]Shaare Zedek Medical Center Jerusalem,Israel,91031[56]Meir Medical Center Kfar Saba,Israel,44281[57]Rabin Medical Center Petah Tikva,Israel,4941492[58]Sheba Medical Center Ramat Gan,Israel,52621[59]Policlinico Hospital San Martino- IRCCS for Oncology Genova,Italy,16132[60]Ospedale San Raffaele Milano,Italy,20132[61]ASST Grande Ospedale Metropolitano Niguarda Milano,Italy,20162[62]Azienda Ospedaliera San Gerardo Monza,Italy,20090[63]Azienda Ospedaliera Specialistica dei Colli Naples,Italy,80131[64]National Hospital Organization Himeji Medical Center Himeji,Japan,670-8520[65]Matsusaka Municipal Hospital Matsusaka,Japan,515-8544[66]Niigata Cancer Center Hospital Niigata,Japan,951-8566[67]Shizuoka Cancer Center Shizuoka,Japan,411-8777[68]The Cancer Institute Hospital of JFCR Tokyo,Japan,135-8550[69]Wakayama Medical University Hospital Wakayama,Japan,641-8510[70]National Cancer Center Goyang-Si,Korea,Republic of,10408[71]Seoul National University Bundang Hospital Gyeonggi-do,Korea,Republic of,13620[72]Seoul National University Hospital Seoul,Korea,Republic of,03080[73]Severance Hospital,Yonsei University Health System Seoul,Korea,Republic of,03722[74]Asan Medical Center Seoul,Korea,Republic of,05505[75]University Malaya Medical Centre Kuala Lumpur,Malaysia,59100[76]Hospital Tengku Ampuan Afzan Kuantan,Malaysia,25100[77]Hospital Umum Sarawak Kuching,Malaysia,93586[78]Beacon Hospital Sdn. Bhd. Petaling Jaya,Malaysia,46050[79]Hosp. Univ. A Coruña A Coruña,Spain,15006[80]General University Hospital of Alicantet Alacant,Spain,03010[81]Hosp. de La Santa Creu I Sant Pau Barcelona,Spain,08025[82]Hosp. Univ. Vall D Hebron Barcelona,Spain,08035[83]Hosp. Del Mar Barcelona,Spain,8003[84]Inst. Cat. Doncologia-H Duran I Reynals Barcelona,Spain,8908[85]Hosp. Gral. Univ. Gregorio Marañon Madrid,Spain,28007[86]Hosp. Univ. Ramon Y Cajal Madrid,Spain,28034[87]Hosp. Univ. La Paz Madrid,Spain,28046[88]Hosp. Univ. 12 de Octubre Madrid,Spain,28051[89]Hosp. Regional Univ. de Malaga Malaga,Spain,29010[90]Hosp. Virgen Macarena Sevilla,Spain,41009[91]Hosp. Clinico Univ. de Valencia Valencia,Spain,46010[92]Hosp. Gral. Univ. Valencia Valencia,Spain,46014[93]Bristol Haematology and Oncology Centre Bristol,United Kingdom,BS2 8ED[94]Torbay Hospital-Devon Devon,United Kingdom,TQ2 7AA[95]Edinburgh Cancer Centre Western General Edinburgh,United Kingdom,EH4 2XU[96]Leicester Royal Infirmary Leicester,United Kingdom,LE1 5WW[97]University College London Hospitals London,United Kingdom,NW1 2PG[98]Sarah Cannon Research Institute London,United Kingdom,W1G 6AD[99]Southampton University Hospital Southampton,United Kingdom,SO16 6YD
研究目的：
The purpose of this study is to assess the anti-tumor activity of amivantamab subcutaneous administered as a Co-Formulation (SC-CF) with recombinant human hyaluronidase PH20 (rHuPH20) (Cohorts 1, 2, and 3) in combination treatment and to characterize the safety of amivantamab SC-CF (Cohort 4).
