研究单位：[1]Janssen Research & Development,LLC[2]University of Alabama at Birmingham,Comprehensive Cancer Center Birmingham,Alabama,United States,35233[3]UCLA Los Angeles,California,United States,90095[4]University of California,Irvine Orange,California,United States,92868[5]The Oncology Institute of Hope and Innovation Whittier,California,United States,90603[6]University of Chicago Chicago,Illinois,United States,60637-1426[7]Montefiore Einstein Center for Cancer Care Bronx,New York,United States,10467[8]University of North Carolina Chapel Hill,North Carolina,United States,27599-1651[9]Providence Portland Medical Center Portland,Oregon,United States,97213[10]Virginia Cancer Specialists Fairfax,Virginia,United States,22031[11]VCU Medical Center Richmond,Virginia,United States,23219[12]Medical College Of Wisconsin Milwaukee,Wisconsin,United States,53226[13]PERSONAL - Oncologia de Precisão e Personalizada Belo Horizonte,Brazil,30130-090[14]CIONC - Centro Integrado de Oncologia de Curitiba Curitiba,Brazil,80810-050[15]UPCO Unidade de Pesquisa Clinica em Oncologia Pelotas,Brazil,96020 080[16]União Brasileira de Educação e Assistência-Hospital São Lucas da PUCRS Porto Alegre,Brazil,90610-000[17]Oncoclínicas Rio de Janeiro S.A. Rio de Janeiro,Brazil,22250-905[18]Instituto D'Or de Pesquisa e Ensino (IDOR) Rio de Janeiro,Brazil,22281-100[19]Núcleo de Oncologia da Bahia Salvador,Brazil,40170-110[20]Fundação Antônio Prudente - A.C. Camargo Cancer Center Sao Paulo,Brazil,01509900[21]Sociedade Beneficente de Senhoras - Hospital Sírio Libanês São Paulo,Brazil,01308-901[22]The Ottawa Hospital Research Institute Ottawa,Ontario,Canada,K1Y 4E9[23]University Health Network (UHN) Princess Margaret Cancer Centre Toronto,Ontario,Canada,M5G 1Z5[24]Beijing Cancer Hospital Beijing,China,100142[25]Sichuan Cancer Hospital Chengdu,China,610041[26]West China Hospital,Sichuan University Chengdu,China,610041[27]Chongqing University Cancer Hospital Chongqing,China,400030[28]The First Affiliated Hospital,Sun Yat-sen University Guangzhou,China,510060[29]The First Affiliated Hospital,Zhejiang University College of Medicine Hangzhou,China,310003[30]Second Affiliated Hospital,School of Medicine,Zhejiang University Hangzhou,China,310009[31]Sir Run Run Shaw Hospital,Zhejiang University School of Medicine Hangzhou,China,310016[32]Harbin medical university cancer hospital Harbin,China,150081[33]Huizhou Municipal Central Hospital Huizhou,China,516001[34]Fudan University Shanghai Cancer Center Shanghai,China,200032[35]Shanghai Pulmonary Hospital Shanghai,China,200433[36]Shengjing Hospital of China Medical University Shenyang,China,110055[37]The First Affiliated Hospital of Xi'an Jiaotong University Xi'An,China,710061[38]Yantai Yuhuangding Hospital Yantai,China,264000[39]Henan Cancer Hospital Zhengzhou,China,450008[40]Institute Coeur Poumon Lille,France,59000[41]Centre Leon Bérard Lyon Cedex 8,France,69008[42]CHU de la Timone Marseille,France,13005[43]Institut Curie PARIS Cedex 5,France,75248[44]Institut de cancerologie de l'ouest Saint-Herblain Cedex,France,44805[45]Nouvel Hopital Civil - CHU Strasbourg Strasbourg cedex,France,67091[46]Charite Universitaetsmedizin Berlin Berlin,Germany,12203[47]Helios Klinikum Emil von Behring GmbH Berlin,Germany,14165[48]Klinikum Chemnitz gGmbH Chemnitz,Germany,09116[49]Universitaetsklinikum Carl Gustav Carus TU Dresden Dresden,Germany,01307[50]Universitaetsklinikum Essen Essen,Germany,45147[51]Universitaetsklinikum Koeln Koeln,Germany,50937[52]Universitaetsklinikum Muenster Muenster,Germany,48149[53]Munchen Klinik GmbH Klinik Bogenhausen München,Germany,81925[54]Fondazione IRCCS Istituto Nazionale dei Tumori Milano,Italy,20133[55]ASST Grande Ospedale Metropolitano Niguarda Milano,Italy,20162[56]Fondazione G. Pascale - Istituto Nazionale Tumori IRCCS Napoli,Italy,80131[57]Istituto Oncologico Veneto - IRCCS Padova,Italy,35128[58]Ospedale S. Maria Delle Croci Ravenna,Italy,48121[59]Istituto Nazionale Tumori Regina Elena Rome,Italy,00128[60]National Hospital Organization Nagoya Medical Center Nagoya-shi,Japan,460-0001[61]Shizuoka Cancer Center Sunto-gun,Japan,411-8777[62]The Cancer Institute Hospital of JFCR Tokyo,Japan,135-8550[63]Chungbuk National University Hospital Cheongju-si,Korea,Republic of,28644[64]National Cancer Center Goyang-Si,Korea,Republic of,10408[65]Gachon University Gil Hospital Incheon,Korea,Republic of,21565[66]Chonnam National University Hwasun Hospital Jeollanam-do,Korea,Republic of,58128[67]Seoul National University Bundang Hospital Seongnam,Korea,Republic of,13620[68]Seoul National University Hospital Seoul,Korea,Republic of,03080[69]Severance Hospital,Yonsei University Health System Seoul,Korea,Republic of,03722[70]Asan Medical Center Seoul,Korea,Republic of,05505[71]Uniwersyteckie Centrum Kliniczne Gdansk,Poland,80-214[72]INSTYTUT GENETYKI I IMMUNOLOGII GENIM Sp. z o.o. Lublin,Poland,20-609[73]Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy Warszawa,Poland,02-781[74]Hosp. Univ. A Coruña A Coruña,Spain,15006[75]Hosp. Gral. Univ. de Alicante Alicante,Spain,03010[76]Hosp. Del Mar Barcelona,Spain,08003[77]Hosp. Univ. Quiron Dexeus Barcelona,Spain,08028[78]Hosp. Univ. Vall D Hebron Barcelona,Spain,08035[79]Hosp. Clinic I Provincial de Barcelona Barcelona,Spain,08036[80]Hosp. Univ. Fund. Jimenez Diaz Madrid,Spain,28040[81]Hosp. Univ. 12 de Octubre Madrid,Spain,28041[82]Hosp. Univ. La Paz Madrid,Spain,28046[83]Hosp. Virgen Macarena Sevilla,Spain,41009[84]Hosp. Clinico Univ. de Valencia Valencia,Spain,46010[85]Memorial Ankara Hastanesi Ankara,Turkey,06520[86]Gazi University Hospital Ankara,Turkey,06560[87]Ankara Bilkent City Hospital Ankara,Turkey,06590[88]Liv Hospital Ankara Ankara,Turkey,06680[89]Istanbul University Cerrahpasa Medical Faculty Istanbul,Turkey,34098[90]Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi Istanbul,Turkey,34722[91]UCL Cancer Institute London,United Kingdom,NW1 2PG[92]Imperial College London and Imperial College Healthcare NHS Trust London,United Kingdom,W2 1NY[93]Freeman Hospital Newcastle,United Kingdom,NE7 7DN[94]Royal Marsden Hospital Sutton,United Kingdom,SM2 5PT
研究目的：
The purpose of this study is to identify the recommended Phase 2 combination dose (RP2CD[s]) of the amivantamab and capmatinib combination therapy in participants with non-small cell lung cancer (NSCLC) in Phase 1 (combination dose selection), and to evaluate the antitumor effect of the amivantamab and capmatinib combination therapy in mesenchymal-epithelial transition (MET) exon 14 skipping mutation and MET amplified NSCLC, when administered at the selected RP2CD(s) in Phase 2 (expansion).
