Tislelizumab combined with chemotherapy sequential neoadjuvant therapy for non-cCR patients after neoadjuvant chemoradiotherapy in locally advanced ESCC. And then the patients would receive surgery and adjuvant therapy according to the postoperative pathological results. It is expected that through this study,some high-risk patients could obtain better efficacy and prolong patient survival. At same time,low risk patients could avoid increasing perioperative complications and surgical risks,so that more patients could benefit from neoadjuvant treatment. The investigators aimed to explore a more accurate comprehensive treatment mode for patients with esophageal squamous cell carcinoma,and provide a certain scientific basis for the formulation of esophageal cancer diagnosis and treatment norms in China.