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与新辅助化疗和辅助内分泌治疗联合用于治疗 ER+/HER2-乳腺癌的纳武利尤单抗和安慰剂比较

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研究单位: [1]复旦大学附属肿瘤医院 [2]Instituto De Oncologia Angel H Roffo [3]Hospital Italiano De Cordoba [4]Breast Clinic [5]Cemic [6]Centro Oncologico Ribjero Integral [7]Hospital Britanico De Buenos Aires [8]Centro de Investigaciones Clinicas. Clinica Viedma S. A [9]Instituto Medico Especialazado Alexander Fleming [10]Hospital Provincial Del Centenario [11]Clinica Adventista Belgrano [12]Port Macquarie Base Hospital [13]Ballarat Base Hospital [14]Mater Hospital [15]Royal Brisbane and Womens Hospital [16]Calvary Central Districts Hospital [17]Monash Medical Centre Clayton [18]Austin Hospital [19]Medizinische Universitaet Wien [20]Med. Universitaet Innsbruck [21]Landeskrankenhaus-Universitaetsklinik fuer Innere Medizin III [22]Universitaetsklinik F. Frauenheilkunde / Geburtshilfe [23]Medizinische Universitaet Wien [24]Grand Hopital De Charleroi [25]Universitair Ziekenhuis Gent [26]Universitair Ziekenhuis Brussel [27]CHU de Liège [28]Universitair Ziekenhuis Antwerpen [29]Associacao Hospital de Caridade Ijui [30]Oncocentro Servico Medicos e Hospitalares Ltda [31]Centro de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria [32]COI Clinicas Oncologicas Integradas SA [33]Universidade Federal De Minas Gerais [34]Hospital Municipal Vila Santa Catarina [35]Faculdade De Medicina Do Abc [36]Irmandade da Santa Casa de Misericordia de Porto Alegre - Hospital Santa Rita [37]Fundacao Pio Xii Hosp Cancer De Barretos [38]Hospital Sao Lucas Da Pucrs [39]Hospital Sirio Libanes [40]Thunder Bay Regional Health Science Centre [41]Jewish General Hospital [42]St. Marys Hospital [43]Centre integre universitaire de sante et de service sociaux de l'estrie - CHUS [44]Humber River Regional Hospital [45]Kingston Health Sciences Centre Kingston General Hospital Site [46]CHUM [47]Oncocentro Apys [48]IC La Serena Research [49]Centro de Investigacion Clinica Bradford Hill [50]Hospital Clinico Pontificia Universidad Catolica De Chile [51]Clinica de la Costa LTDA [52]Clinica Del Country [53]Fundacion Cardiovascular De Colombia [54]Oncomedica S.A. [55]Hemato Oncologos S.A. [56]Instituto Nacional De Cancerologia [57]Centros Especializados San Vicente Fundacion [58]Radioterapeuticka a onkologicka klinika FNKV [59]Onkologicke oddeleni [60]Onkologicka klinika [61]Klinika onkologie a radioterapie [62]Komplexni onkologicke centrum [63]Rigshospitalet [64]Naestved Sygehus [65]Aarhus Universitetshospital [66]Herlev University Hospital [67]Helsinki University Hospital [68]Tampere University Hospital [69]Clinique Victor Hugo [70]Institut De Cancerologie De L Ouest [71]Chu Jean Minjoz [72]Institut du Cancer de Montpellier [73]Hopital Morvan [74]Institut Gustave Roussy [75]Hopital Prive Jean Mermoz [76]H?pital Privé Des C?tes d'Armor [77]Hopital Europeen Georges Pompidou [78]Centre Jean Perrin [79]Clinique Sainte Anne [80]Universitatsklinikum Leipzig [81]CaritasKlinikum Saarbruecken. [82]Evang. Krankenhaus Bethesda [83]Klinikum der Universitaet Muenchen [84]Universitaetsklinikum Essen [85]Universitaetsklinikum Koeln Koeln [86]MVZ-Onkologie Velbert GbR [87]Uni Frauenklinikum Suedstadt [88]Univ. Klinikum Wuerzburg [89]Universitaetsklinik Heidelberg [90]Klinikum Der Johann Wolfgang Goethe-Universitat [91]Universitaetsklinikum d. Saarlandes [92]Agaplesion Diakonieklinikum [93]Helios Klinikum Berlin-Buch [94]Universitaetsklinikum Carl Gustav Carus [95]Queen Mary Hospital [96]St. James'S Hospital [97]Beaumont Hospital [98]Cork University Hospital [99]PO Garibaldi Nesima AORN Garibaldi [100]Istituto Europeo Di Oncologia [101]Istituto Oncologico Veneto IOV [102]Istituto Nazionale Tumori Fondazione Pascale [103]Azienda Ospedaliero Universitaria Federico II di Napoli [104]Fondazione Irccs - Policlinico San Matteo [105]ASST Papa Giovanni XXIII [106]Istituto Clinico Humanitas [107]Azienda Ospedaliero-Universitaria Mater Domini [108]Policlinico Universitario Campus Biomedico Di Roma [109]Consultorio del Dr. Oscar Nicolas Avila Zamora [110]Instituto Nacional De Cancerologia [111]Centro Estatal de Cancerologia [112]Consultorio de Medicina Especializada CME [113]Merida Investigacion Clincia [114]Consultorio Medico Dr. Julio Cesar Zepeda Najar [115]'Consultorio del Dr. Joaquín Gabriel Reinoso Toledo' [116]Consultorio de Oncología Médica [117]Merida Investigacion Clincia [118]Umc Utrecht [119]Deventer Ziekenhuis [120]Erasmus Medisch Centrum [121]Antoni Van Leeuwenhoek Ziekenhuis [122]Amphia Ziekenhuis [123]Klinika Onkologii CZMP [124]Oddzial Dzienny Chemioterapii [125]Klinika Nowotworow Piersi i Chirurgii Rekonstrukcyjnej [126]Oddzial Onkologii Klinicznej z Odcinkiem Dziennym [127]Oddzial Kliniczny Onkologii [128]Instituto Portugues de Oncologia do Porto EPE [129]Hospital da Luz [130]Hospital De Santa Maria [131]County Emergency Hospital Suceava [132]Filantropia Clinical Hospital [133]SF. NECTARIE ONCOLOGY CENTER [134]SC Radiotherapy Center Cluj SRL [135]Inst.Oncologic Prof.Dr.Al.Trestioreanu Sectia Ocologie Medicala I [136]Privolzhsky Regional Medical Center of Fed. Medical agency [137]State Budgetary Med Institu Krasnodar Clinical Onco Disp #1 [138]N.N. Blokhin National Medical Research Center of Oncology. [139]Oncology Center # 2 [140]Tan Tock Seng Hospital [141]National University Hospital [142]National Cancer Centre [143]Hospital Universitario Virgen De La Victoria [144]Centro Integral Oncologico Clara Campal [145]Hospital Clinico San Carlos [146]Clinica Universidad de Navarra [147]Hospital Clinic I Provincial [148]Hospital Clinico Univ. de Santiago-CHUS [149]Hospital General Universitario Elche [150]HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO [151]H. Univ. Vall dHebron [152]Onkologiezentrum Thun-Berner Oberland Spital Sts Ag [153]University Hospital Basel [154]CHUV [155]Adana Sehir Egitim ve Arastirma Hastanesi [156]Memorial Ankara Hospital [157]Istanbul Universitesi Cerrahpasa Tip Fakultesi Onkoloji [158]Akdeniz Universitesi Tip Fakultesi [159]Norton Brownsboro Hospital [160]AdventHealth Orlando [161]Montefiore Medical Center [162]Marin Cancer Care,Inc [163]Ft. Wayne Med Onco-Hema Inc [164]New England Cancer Specialists [165]Hunterdon Hematology Oncology [166]University of New Mexico Comprehensive Cancer Center [167]Tennessee Oncology,PLLC - SCRI - PPDS [168]Ponce Medical School Foundation [169]Sacred Heart Medical Group [170]Rutgers Cancer Institute of New Jersey [171]Northwestern University [172]HCA Midwest Division [173]Inova Schar Cancer Institute [174]Forsyth Memorial Hospital [175]Utah Cancer Specialists [176]Bennett Cancer Center [177]Cedars Sinai Medical Center [178]Good Samaritan Hospital [179]University Cancer Blood Ctr [180]Summit Medical Group [181]John B. Amos Cancer Center [182]University of South Alabama Mitchell Cancer Institute [183]American Oncology Partners of Maryland,PA [184]Tallahassee Memorial Cancer Center [185]Duke University Medical Center [186]MetroHealth Medical Center [187]Innovative Clinical Research Institute [188]Cancer Specialists of North FL [189]University of Miami [190]Hematology-Oncology Associates Of Fredricksburg,Inc [191]The Cancer Center At Hackensack University Medical Center [192]Virginia Cancer Institute [193]Ft. Worth Center For Cancer Blood Disorders [194]Northside Hospital,Inc.- Central Research Department [195]The Christie NHS Foundation Trust [196]University Hospitals Coventry And Warwickshire [197]Singleton Hospital [198]University College London Hospital [199]Churchill Hospital [200]烟台毓璜顶医院 [201]北京大学人民医院 [202]浙江大学医学院附属第一医院 [203]重庆大学附属肿瘤医院 [204]河南省肿瘤医院 [205]蚌埠医学院第一附属医院 [206]浙江大学医学院附属第二医院 [207]浙江大学医学院附属邵逸夫医院 [208]中国科学技术大学附属第一医院(安徽省立医院) [209]河北医科大学第四医院 [210]广东省人民医院 [211]四川省肿瘤医院 [212]山东省肿瘤防治研究院(山东省肿瘤医院) [213]吉林大学第一医院 [214]哈尔滨医科大学附属肿瘤医院 [215]华中科技大学同济医学院附属协和医院 [216]天津市肿瘤医院(天津医科大学肿瘤医院) [217]辽宁省肿瘤医院 [218]四川大学华西医院 [219]青岛大学附属医院 [220]吉林省肿瘤医院 [221]西安交通大学第一附属医院 [222]中山大学肿瘤防治中心 [223]新疆医科大学附属肿瘤医院 [224]遵义医科大学附属医院 [225]重庆医科大学附属第一医院 [226]中山大学附属第一医院

研究目的:
比较新辅助治疗的Nivolumab/安慰剂联合化疗残留肿瘤疾病。 比较Nivolumab/安慰剂新辅助化疗和辅助 ET联用的EFS和生存期。 比较Nivolumab/安慰剂新辅助化疗联用的残留疾病的存在,安全性和耐受性,总体健康状态/QOL和身体功能较基线变化。

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