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A Prospective Multi-center Clinical Study on Precise Guidance of Adaptive Radiotherapy for Nasopharyngeal Carcinomar by Multi-dimensional Molecular Imaging

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研究单位: [1]The First Affiliated Hospital of Xiamen University,The First Affiliated Hospital of Xiamen University [2]Sun Yat-sen University [3]Peking University Shenzhen Hospital [4]Sichuan Cancer Hospital and Research Institute [5]Shandong Cancer Hospital and Institute [6]Union Hospital, Tongji Medical College, Huazhong University of Science and Technology [7]Shenzhen Yino Intelligence Technology Development Co.,Ltd.

研究目的:
The goal of this observational study is to evaluate the performance of 68Ga-FAPI-LM3 PET/CT imaging parameters for staging nasopharyngeal carcinoma (NPC) and to investigate whether 68Ga-PD-L1 PET/CT imaging parameters can predict response to neoadjuvant immunotherapy in NPC. The study will assess the sensitivity and specificity of each tracer for staging and for predicting therapeutic response, analyze changes in tumor uptake parameters on 68Ga-FAPI-LM3 and 68Ga-PD-L1 PET/CT before and after treatment, and compare treatment efficacy and survival outcomes between patients with different degrees of residual PET uptake and between those who did and did not receive neoadjuvant immunotherapy. The primary question it aims to answer is: Does 68Ga-FAPI-LM3 PET/CT improve the accuracy of NPC staging, and can 68Ga-PD-L1 PET/CT imaging parameters provide an early prediction of response to neoadjuvant immunotherapy? Participants will be patients with biopsy-proven nasopharyngeal carcinoma who undergo 68Ga-FAPI-LM3 and/or 68Ga-PD-L1 PET/CT as part of clinical care or a research protocol. Tumor uptake metrics (e.g., SUVmax, SUVmean, metabolic/volumetric indices) will be measured pre- and post-treatment; diagnostic performance (sensitivity, specificity) and associations between uptake changes and clinical outcomes (response rates, progression-free and overall survival) will be calculated.

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