A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
研究单位：[1]Merck Sharp & Dohme LLC[2]Public Non-Profit Enterprise Kyiv City Clinical Hospital #9 under the Executive Body of Kyiv City Co,Kyiv,Ukraine,04112[3]Cancer Blood and Specialty Clinic ( Site 0109),Los Alamitos,California,United States,90720[4]Cancer Care Specialists of Illinois ( Site 0152),O''Fallon,Illinois,United States,62269[5]Fort Wayne Medical Oncology and Hematology ( Site 0149),Fort Wayne,Indiana,United States,46804[6]Cotton O''Neil Cancer Center ( Site 0108),Topeka,Kansas,United States,66606[7]Truman Medical Center ( Site 0122),Kansas City,Missouri,United States,64108[8]OptumCare Cancer Care ( Site 0121),Las Vegas,Nevada,United States,89102[9]Comprehensive Cancer Centers of Nevada ( Site 0113),Las Vegas,Nevada,United States,89169[10]New York Oncology Hematology, P.C. ( Site 0129),Albany,New York,United States,12206[11]University of Virginia Cancer Center ( Site 0138),Charlottesville,Virginia,United States,22903[12]Virginia Cancer Institute ( Site 0148),Richmond,Virginia,United States,23229[13]Blue Ridge Cancer Care ( Site 0132),Roanoke,Virginia,United States,24014[14]SSM Health Dean Medical Group ( Site 0140),Madison,Wisconsin,United States,53715[15]Instituto de Investigaciones Clinicas Mar del Plata ( Site 0306),Mar del Plata,Buenos Aires,Argentina,B7600FZO[16]Fundacion Estudios Clinicos ( Site 0311),Rosario.,Santa Fe,Argentina,S2000CEJ[17]Hospital Italiano de Buenos Aires ( Site 0304),Caba,Argentina,C1199ABB[18]ASBL CHU Helora - Hôpital de Mons - Site Kennedy ( Site 1103),Mons,Hainaut,Belgium,7000[19]Hospital Erasto Gaertner ( Site 0401),Curitiba,Parana,Brazil,82520-060[20]Liga Norte Riograndense Contra o Cancer ( Site 0407),Natal,Rio Grande Do Norte,Brazil,59062-000[21]CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina ( Site 0403),Florianópolis,Santa Catarina,Brazil,88020-210[22]Hope ( Site 0413),Ribeirao Preto,Sao Paulo,Brazil,14026-610[23]Clinica Advanze ( Site 0411),Sao Carlos,Sao Paulo,Brazil,13561-130[24]F. F. R. M. São Jose do Rio Preto ( Site 0404),Sjrp,Sao Paulo,Brazil,15090-000[25]Biocenter ( Site 0510),Concepcion.,Biobio,Chile,4070196[26]Centro de Estudios Clínicos SAGA ( Site 0508),Santiago,Region M. De Santiago,Chile,7500653[27]Beijing Cancer Hospital ( Site 3101),Beijing,Beijing,China,100142[28]Chongqing Cancer Hospital ( Site 3113),Chongqing,Chongqing,China,400030[29]Fujian Provincial Cancer Hospital. ( Site 3119),Fuzhou,Fujian,China,350014[30]Zhujiang Hospital of Southern Medical University ( Site 3122),Guangzhou,Guangdong,China,510280[31]Affiliated Cancer Hospital of Guangxi Medical University ( Site 3123),Nanning,Guangxi,China,530021[32]The Affiliated Hospital of Guizhou Medical University ( Site 3112),Guiyang,Guizhou,China,550004[33]Hubei Cancer Hospital ( Site 3125),Wuhan,Hubei,China,430079[34]Affiliated Hospital of Nantong University ( Site 3117),Nantong,Jiangsu,China,226001[35]Jiangxi Cancer Hospital ( Site 3118),Nanchang,Jiangxi,China,330029[36]Shandong Cancer Hospital ( Site 3108),Jinan,Shandong,China,250117[37]Sichuan Cancer Hospital. ( Site 3111),Chengdu,Sichuan,China,610041[38]West China Hospital, Sichuan University ( Site 3110),Chengdu,Sichuan,China,610041[39]Institute of Hematology and Blood Diseases Hosp CAMS&PUMC ( Site 3105),Tianjin,Tianjin,China,301617[40]Yunnan Province Cancer Hospital ( Site 3109),Kunming,Yunnan,China,650118[41]The First Affiliated Hospital, Zhejiang Medical University ( Site 3116),Hangzhou,Zhejiang,China,310009[42]Hospital Pablo Tobon Uribe ( Site 0604),Medellin,Antioquia,Colombia,050034[43]IMAT S.A.S ( Site 0603),Montería,Cordoba,Colombia,230002[44]Hospital Universitario San Ignacio ( Site 0607),Bogota.,Distrito Capital De Bogota,Colombia,110231[45]Oncologos del Occidente ( Site 0601),Pereira.,Risaralda,Colombia,660001[46]Fundación Valle del Lili ( Site 0602),Cali,Valle Del Cauca,Colombia,760032[47]Aalborg University Hospital ( Site 1302),Aalborg,Nordjylland,Denmark,9000[48]CHU Dijon Bourgogne ( Site 1516),Dijon,Cote-d Or,France,21000[49]Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1512),Limoges,Limousin,France,87042[50]Centre Hospitalier Régional Metz Thionville - Hôpital de Mercy ( Site 1515),Metz,Moselle,France,57085[51]Centre Hospitalier de Dunkerque ( Site 1513),Dunkerque,Nord,France,59385[52]Centre Hospitalier de la Cote Basque ( Site 1509),Bayonne,Pyrenees-Atlantiques,France,64100[53]HIA Sainte Anne ( Site 1506),Toulon,Var,France,83800[54]Centre Hospitalier d''Avignon ( Site 1505),Avignon,Vaucluse,France,84000[55]CHD Vendee ( Site 1502),La Roche-sur-Yon,Vendee,France,85000[56]CELAN,S.A ( Site 0702),Guatemala.,Guatemala,01010[57]MEDI-K ( Site 0701),Guatemala,Guatemala,01009[58]Cen Integral Onco Gastro y Hemato Onco Guatemala S.A. ( Site 0703),Guatemala,Guatemala,01010[59]Princess Margaret Hospital ( Site 3202),Hong Kong,Hong Kong[60]Queen Mary Hospital ( Site 3201),Hong Kong,Hong Kong[61]Carmel Hospital ( Site 1903),Haifa,Israel,3436212[62]Hadassah Medical Center ( Site 1901),Jerusalem,Israel,9112001[63]Sourasky Medical Center ( Site 1904),Tel Aviv,Israel,6423906[64]Poria Medical Center ( Site 1902),Tiberias,Israel,15208[65]Istituto di Candiolo IRCCS - Fondazione del Piemonte per l''Oncologia ( Site 2010),Candiolo,Torino,Italy,10060[66]AOU delle Marche Ospedali Riuniti di Ancona ( Site 2011),Ancona,Italy,60126[67]IEO Istituto Europeo di Oncologia ( Site 2009),Milano,Italy,20141[68]Ospedale Santa Maria delle Croci ( Site 2006),Ravenna,Italy,48121[69]Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore (,Roma,Italy,00168[70]Nagoya University Hospital ( Site 3309),Nagoya,Aichi,Japan,466-8560[71]National Hospital Organization Shikoku Cancer Center ( Site 3321),Matsuyama,Ehime,Japan,791-0280[72]Kobe City Medical Center General Hospital ( Site 3318),Kobe,Hyogo,Japan,650-0047[73]Kanazawa University Hospital ( Site 3308),Kanazawa,Ishikawa,Japan,920-8641[74]Tokai University Hospital ( Site 3302),Isehara,Kanagawa,Japan,259-1193[75]Tohoku University Hospital ( Site 3301),Sendai,Miyagi,Japan,980-8574[76]Kindai University Hospital ( Site 3310),Osakasayama,Osaka,Japan,589-8511[77]Saitama Medical University Hospital ( Site 3305),Iruma-gun,Saitama,Japan,350-0495[78]Juntendo University Hospital ( Site 3307),Bunkyo,Tokyo,Japan,113-8431[79]University of Yamanashi Hospital ( Site 3320),Chuo,Yamanashi,Japan,409-3898[80]Chiba Cancer Center ( Site 3314),Chiba,Japan,260-8717[81]Kyushu University Hospital ( Site 3313),Fukuoka,Japan,812-8582[82]Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital ( Site 3322),Hiroshima,Japan,730-8619[83]University Hospital,Kyoto Prefectural University of Medicine ( Site 3315),Kyoto,Japan,602-8566[84]University of Miyazaki Hospital ( Site 3319),Miyazaki,Japan,889-1692[85]Okayama University Hospital ( Site 3311),Okayama,Japan,700-8558[86]Osaka Metropolitan University Hospital ( Site 3317),Osaka,Japan,545-8586[87]Yamagata University Hospital ( Site 3312),Yamagata,Japan,990-9585[88]National Cancer Center- Center for Hemotologic malignancy ( Site 3806),Goyang-si,Kyonggi-do,Korea, Republic of,10408[89]Pusan National University Hospital ( Site 3804),Busan,Pusan-Kwangyokshi,Korea, Republic of,49241[90]Chungnam National University Hospital ( Site 3801),Daejeon,Taejon-Kwangyokshi,Korea, Republic of,35015[91]Severance Hospital, Yonsei University Health System ( Site 3802),Seoul,Korea, Republic of,03722[92]Samsung Medical Center ( Site 3807),Seoul,Korea, Republic of,06351[93]St.Mary''s H., Youido ( Site 3805),Seoul,Korea, Republic of,07345[94]Queen Elizabeth Hospital ( Site 3405),Kota Kinabalu,Sabah,Malaysia,88586[95]Hospital Miri ( Site 3403),Miri,Sarawak,Malaysia,98000[96]Meander Medisch Centrum ( Site 2101),Amersfoort,Utrecht,Netherlands,3813 TZ[97]Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2201),Warszawa,Mazowieckie,Poland,02-781[98]Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku ( Site 2210),Słupsk,Pomorskie,Poland,76-200[99]Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2208),Gliwice,Slaskie,Poland,44-102[100]Pratia Onkologia Katowice ( Site 2204),Katowice,Slaskie,Poland,40-519[101]Szpital Kliniczny Ministerstwa Spraw Wewnętrznych i Administracji z Warmińsko-Mazurskim Centrum Onko,Olsztyn,Warminsko-mazurskie,Poland,10-228[102]BRCR Global - Mayaguez ( Site 1003),Mayaguez,Puerto Rico,00682[103]Auxilio Mutuo Cancer Center ( Site 1001),San Juan,Puerto Rico,00918[104]Institutul Oncologic Cluj ( Site 2404),Cluj-Napoca,Cluj,Romania,4003437[105]Spital Judetean Sibiu ( Site 2405),Sibiu,Romania,550245[106]National Cancer Centre Singapore ( Site 3701),Singapore,Central Singapore,Singapore,168583[107]Hospital Universitario Virgen Macarena ( Site 2608),Sevilla,Andalucia,Spain,41009[108]H. Insular de Gran Canaria ( Site 2606),Las Palmas de Gran Canaria,Las Palmas,Spain,35016[109]Hospital General Universitario Dr. Balmis ( Site 2604),Alicante,Valenciana, Comunitat,Spain,03010[110]Hospital del Mar ( Site 2610),Barcelona,Spain,08003[111]Hospital Universitario La Paz ( Site 2611),Madrid,Spain,28046[112]Hospital Virgen de la Victoria ( Site 2609),Malaga,Spain,29010[113]Ospedale Regionale Bellinzona e Valli ( Site 2701),Bellinzona,Ticino,Switzerland,6501[114]National Cheng Kung University Hospital ( Site 3902),Tainan,Taiwan,704[115]Mackay Memorial Hospital ( Site 3908),Taipei,Taiwan,10049[116]National Taiwan University Hospital ( Site 3901),Taipei,Taiwan,100[117]Tri-Service General Hospital ( Site 3906),Taipei,Taiwan,11490[118]Chang Gung Memorial Hospital - Linkou Branch ( Site 3903),Taoyuan,Taiwan,333[119]MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( S,Cherkasy,Cherkaska Oblast,Ukraine,18009[120]Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council" ( Si,Ivano-Frankivsk,Ivano-Frankivska Oblast,Ukraine,76008[121]Khmelnytskyi Regional Hospital ( Site 2907),Khmelnytskiy,Khmelnytska Oblast,Ukraine,29000[122]Institute of Blood Pathology and Transfusion Medicine AMS Ukraine ( Site 2903),Lviv,Lvivska Oblast,Ukraine,79057[123]SNPE National Cancer Institute ( Site 2902),Kyiv,Ukraine,03022[124]Universal Clinic Oberig ( Site 2908),Kyiv,Ukraine,03057
The purpose of this study is to evaluate if zilovertamab vedotin with standard treatment can help people live longer without the cancer growing or spreading than people who receive standard treatment alone.
